"Prognostic Prediction, Immune Microenvironment, and Drug Resistance Value of Collagen Type I Alpha 1 Chain: From Gastrointestinal Cancers to Pan-Cancer Analysis"

作者全名："Liu, Yi; Xue, Jinmin; Zhong, Maoxi; Wang, Zhi; Li, Jie; Zhu, Yuxi"

作者地址："[Liu, Yi; Xue, Jinmin; Zhong, Maoxi; Wang, Zhi; Li, Jie; Zhu, Yuxi] Chongqing Med Univ, Dept Oncol, Affiliated Hosp 1, Chongqing, Peoples R China; [Liu, Yi; Xue, Jinmin; Zhong, Maoxi; Wang, Zhi; Li, Jie; Zhu, Yuxi] Chongqing Med Univ, Jinshan Hosp, Dept Oncol, Affiliated Hosp 1, Chongqing, Peoples R China; [Liu, Yi; Xue, Jinmin; Zhong, Maoxi; Wang, Zhi; Li, Jie; Zhu, Yuxi] Chongqing Med Univ, Chongqing Clin Canc Res Ctr, Affiliated Hosp 1, Chongqing, Peoples R China"

通信作者："Zhu, YX (通讯作者)，Chongqing Med Univ, Dept Oncol, Affiliated Hosp 1, Chongqing, Peoples R China.; Zhu, YX (通讯作者)，Chongqing Med Univ, Jinshan Hosp, Dept Oncol, Affiliated Hosp 1, Chongqing, Peoples R China.; Zhu, YX (通讯作者)，Chongqing Med Univ, Chongqing Clin Canc Res Ctr, Affiliated Hosp 1, Chongqing, Peoples R China."

来源：FRONTIERS IN MOLECULAR BIOSCIENCES

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:000685121900006

JCR分区：Q2

影响因子：5

年份：2021

卷号：8

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：pan-cancer; prognosis; tumor immune microenvironment; gastrointestinal cancers

摘要："Background: Gastrointestinal cancers patients might experience multiple primary tumors in the digestive tract. Therefore, identifying potential biomarkers can help us better understand the underlying mechanism. From the GEO database, four profiles of gastrointestinal cancers were gathered for the screening process, and six hub genes were found by bioinformatics analysis. Collagen type I alpha 1 chain (COL1A1), one of the hub genes, is a component of the extracellular matrix and is critical for tumor microenvironment. However, the expression level, signaling pathway, prognostic prediction, and immunological value of COL1A1 in different cancers remain unclear. Methods: We comprehensively analyzed gene expression and genetic alteration patterns of COL1A1 among 33 types of malignancies from The Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expression projects. Besides, we explored the correlation of COL1A1 with cancer prognosis, immune infiltrates, PD-L1, tumor mutational burden (TMB)/microsatellite instability status (MSI), and the pathway and drug sensitivity of co-expressed genes. Results: The results showed that COL1A1 was highly expressed and associated with poor prognosis in the majority of cancers. The most common alteration type of COL1A1 was missense mutation, and COL1A1 was associated with poor prognosis in KIRP, LGG, MESO, SKCM, and STAD. For the immunologic significance, COL1A1 expression was closely related to high TMB in THYM, LAML, ACC, KICH, PRAD, and LGG, and high MSI in TGCT, MESO, PRAD, COAD, SARC, and CESC. In addition, COL1A1 was positively correlated with the abundance of CAFs, macrophages, and tumor-infiltrating lymphocytes. However, it was negatively correlated with CD8(+) T cells mainly in CESC, HNSC-HPV+, and SKCM. Besides, as a component of the extracellular matrix, COL1A1 was involved in the activation of epithelial-mesenchymal transition (EMT), and high expression of HTRA1 was resistant to multiple drugs. Conclusion: COL1A1 can serve as a prognostic and immunological biomarker in different cancers."

基金机构："Natural Science Foundation Project of Chongqing Science and Technology Commission (CSTC), China [cstc2018jcyjAX0012]"

基金资助正文："This study was supported by the Natural Science Foundation Project of Chongqing Science and Technology Commission (CSTC), China (Grant No. cstc2018jcyjAX0012)."