Causal Effect of Blood Pressure on Bone Mineral Density and Fracture: A Mendelian Randomization Study

作者全名："He, Bin; Yin, Lifeng; Zhang, Muzi; Lyu, Qiong; Quan, Zhengxue; Ou, Yunsheng"

作者地址："[He, Bin; Yin, Lifeng; Zhang, Muzi; Quan, Zhengxue; Ou, Yunsheng] Chongqing Med Univ, Affiliated Hosp 1, Dept Orthoped, Chongqing, Peoples R China; [Lyu, Qiong] Chongqing Med Univ, Affiliated Hosp 1, Dept Gen Practice, Chongqing, Peoples R China"

通信作者："Quan, ZX (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Orthoped, Chongqing, Peoples R China.; Lyu, Q (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Gen Practice, Chongqing, Peoples R China."

来源：FRONTIERS IN ENDOCRINOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000686204200001

JCR分区：Q2

影响因子：5.2

年份：2021

卷号：12

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：blood pressure; bone mineral density; fall; fracture; Mendelian randomization study

摘要："Background: Hypertension may have some association with osteoporosis. This Mendelian randomization (MR) study aimed to explore the causal effect of blood pressure (BP) on bone mineral density (BMD), fall, and fracture. Methods: We used the genome-wide association study (GWAS) summary data among 330,956 European-descent individuals to identify 107 single-nucleotide polymorphisms (SNPs) as the instrumental variables of BP. MR analyses of these instruments were performed on 53,236 European individuals for the association with forearm BMD (FA-BMD), femoral neck BMD (FN-BMD), and lumbar spine BMD (LS-BMD); 451,179 European individuals for fall susceptibility; and up to 1.2 million individuals from European descent for fracture. Conventional inverse variance weighted (IVW) method was adopted to obtain the causal estimates of BP on different outcomes, while weighted median, MR-egger, and MR pleiotropy residual sum and outlier (MR-PRESSO) test were used for sensitivity analyses. Results: Genetically high pulse pressure (PP) could significantly improve FA-BMD (beta-estimate: 0.038, 95% confidence interval [ CI]: 0.013 to 0.063, SE:0.013, P-value=0.003<Bonferroni correction P) in the IVW analysis, indicating that 1-SD increase in PP was associated with the improvement in FA-BMD levels by 0.038 g/cm(2) (95% CI: 0.013 to 0.063). This positive finding was also confirmed by weighted-median analysis (beta-estimate: 0.034, 95% CI: 0.000 to 0.067, SE:0.017, P-value=0.046) and MR-Egger analysis (beta-estimate: 0.117, 95% CI: 0.026 to 0.208, SE:0.046, P-value=0.011). However, there was no remarkable MR association between BP and other outcomes (i.e., FN-BMD, LS-BMD, fall, and fracture). Conclusions: Our findings reveal a potentially causal relationship between high PP and improved FA-BMD, which may provide new sights for the treatment of osteoporosis."

基金机构：Natural Science Foundation of Chongqing [cstc2019jcyj-msxmX0836]; National Natural Science Foundation of China [81701382]; Foundation of The First Affiliated Hospital of Chongqing Medical University [PYJJ2018-13]; Chongqing Yuzhong Nature Science Foundation of China [2018114]

基金资助正文："This study was funded by Natural Science Foundation of Chongqing (cstc2019jcyj-msxmX0836), National Natural Science Foundation of China (81701382), Foundation of The First Affiliated Hospital of Chongqing Medical University (PYJJ2018-13), and Chongqing Yuzhong Nature Science Foundation of China (Grant No. 2018114)."