Sleep problems in children with autism spectrum disorder: a multicenter survey

作者全名："Chen, Hongyu; Yang, Ting; Chen, Jie; Chen, Li; Dai, Ying; Zhang, Jie; Li, Ling; Jia, Feiyong; Wu, Lijie; Hao, Yan; Ke, Xiaoyan; Yi, Mingji; Hong, Qi; Chen, Jinjin; Fang, Shuanfeng; Wang, Yichao; Wang, Qi; Jin, Chunhua; Li, Tingyu"

作者地址："[Chen, Hongyu; Yang, Ting; Chen, Jie; Chen, Li; Dai, Ying; Li, Tingyu] Chongqing Med Univ, Chongqing Key Lab Childhood Nutr & Hlth, Natl Clin Res Ctr Child Hlth & Disorders, Key Lab Child Dev & Disorders,Minist Educ,Childre, Chongqing 400014, Peoples R China; [Zhang, Jie] Xian Childrens Hosp, Xian 710003, Peoples R China; [Li, Ling] Hainan Women & Childrens Med Ctr, Dept Children Rehabil, Haikou 570100, Hainan, Peoples R China; [Jia, Feiyong] First Hosp Jilin Univ, Dept Dev & Behav Pediat, Changchun 130021, Peoples R China; [Wu, Lijie] Harbin Med Univ, Dept Childrens & Adolescent Hlth, Publ Hlth Coll, Harbin 150081, Peoples R China; [Hao, Yan] Huazhong Univ Sci & Technol, Tongji Hosp, Dept Pediat, Tongji Med Coll, Wuhan 430030, Peoples R China; [Ke, Xiaoyan] Nanjing Brain Hosp, Child Mental Hlth Res Ctr, Nanjing 210013, Peoples R China; [Yi, Mingji] Qingdao Univ, Affiliated Hosp, Dept Child Hlth Care, Qingdao 266003, Peoples R China; [Hong, Qi] Maternal & Child Hlth Hosp Baoan, Shenzhen 518133, Peoples R China; [Chen, Jinjin] Shanghai Jiao Tong Univ, Shanghai Childrens Hosp, Dept Child Healthcare, Shanghai 200040, Peoples R China; [Fang, Shuanfeng] Zhengzhou Univ, Childrens Hosp, Zhengzhou 450053, Peoples R China; [Wang, Yichao] Hunan Prov Maternal & Child Hlth Care Hosp, NHC Key Lab Birth Defect Res & Prevent, Changsha 410008, Peoples R China; [Wang, Qi] Deyang Matern & Child Healthcare Hosp, Deyang 618000, Sichuan, Peoples R China; [Jin, Chunhua] Capital Inst Pediat, Dept Children Hlth Care, Beijing 100020, Peoples R China"

通信作者："Li, TY (通讯作者)，Chongqing Med Univ, Chongqing Key Lab Childhood Nutr & Hlth, Natl Clin Res Ctr Child Hlth & Disorders, Key Lab Child Dev & Disorders,Minist Educ,Childre, Chongqing 400014, Peoples R China."

来源：BMC PSYCHIATRY

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:000686622800001

JCR分区：Q2

影响因子：4.4

年份：2021

卷号：21

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Sleep problems; ASD; Children; Sleep hygiene; Multicenter

摘要："Background: High prevalence of sleep problems have been reported in children with Autism Spectrum Disorder (ASD). This study aims to investigate the sleep conditions of ASD children in China, and explore the relationship between the common sleep problems and core symptoms and developmental levels. Methods: Using a cross-sectional design, we included 2 to 7-year-old children from 13 cities in China: 1310 with ASD and 1158 with typically-developing (TD) children. The neurodevelopmental level was evaluated with the revised Children Neuropsychological and Behavior Scale (CNBS-R2016). ASD were diagnosed with DSM-5 and Child Autism Rating Scale (CARS). the Social Responsiveness Scale (SRS), the Autism Behavior Checklist (ABC) and the communication warning behavior sub-scale in CNBS-R2016 valued autism behaviors. The children' s sleep habits questionnaire (CSHQ) assessed sleep conditions. Results: The prevalence of sleep disorders in ASD children was significantly higher than that in TD (67.4% vs. 51%, p < 0.01), and among them the four dimensions with the highest prevalence of sleep problems were bedtime resistance (25.6%), sleep anxiety (22.7%), sleep onset delay (17.9%) and daytime sleepiness (14.7%). ASD children with sleep onset delay or sleep anxiety had higher ABC, SRS scores and higher scores on communication warning behavior with sleep anxiety, with daytime sleepiness had higher ABC, SRS and CARS scores, and with bedtime resistance had higher SRS total scores. Differences in the neurodevelopmental level were not significant. Conclusion: Children with ASD have a higher prevalence of sleep problems. Bedtime resistance, anxiety, sleep onset delay and daytime sleepiness may be related to the core symptoms, but not be related to the developmental level in ASD children. In the clinic, sleep assessment should be included in the routine of ASD visits, and during the intervention, sleep hygiene education is as important as the treatment of biological factors."

基金机构："National Natural Science Foundation of China [81771223, 81770526]; Guangzhou Key Project in ""Early diagnosis and treatment of autism spectrum disorders"" [202007030002]; Guangdong Key Project in ""Development of new tools for diagnosis and treatment of Autism"" [2018B030335001]; Open Project Fund from Key Laboratory of Reproduction Regulation of NHC [KF2018-03]"

基金资助正文："This work was supported by the National Natural Science Foundation of China (No. 81771223, 81770526), the Guangzhou Key Project in ""Early diagnosis and treatment of autism spectrum disorders"" (202007030002), the Guangdong Key Project in ""Development of new tools for diagnosis and treatment of Autism"" (2018B030335001), and the Open Project Fund from Key Laboratory of Reproduction Regulation of NHC (No. KF2018-03)."