Gamma-Glutamyl Transpeptidase to Platelet Ratio: A New Inflammatory Marker Associated with Outcomes after Cardiac Arrest

作者全名："Zhao, Yipin; Lin, Zebin; Ji, Yingying; Wang, Huawei; Li Xiao; Chen, Qingwei; Wu, Zhiqin"

作者地址："[Zhao, Yipin; Lin, Zebin; Wang, Huawei; Li Xiao; Chen, Qingwei; Wu, Zhiqin] Chongqing Med Univ, Dept Gen Med, Affiliated Hosp 2, Chongqing, Peoples R China; [Ji, Yingying] Zhengzhou Univ, Dept Intens Care Unit, Affiliated Hosp 2, Zhengzhou 450014, Peoples R China"

通信作者："Wu, ZQ (corresponding author), Chongqing Med Univ, Dept Gen Med, Affiliated Hosp 2, Chongqing, Peoples R China."

来源：MEDIATORS OF INFLAMMATION

ESI学科分类：IMMUNOLOGY

WOS号：WOS:000687433400001

JCR分区：Q3

影响因子：4.6

年份：2021

卷号：2021

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："Introduction. In recent years, gamma-glutamyl transpeptidase to platelet ratio (GPR) has been proposed as a new inflammatory marker. We aimed to evaluate the association between GPR and outcomes after cardiac arrest (CA). Methods. A total of 354 consecutive patients with CA were included in this retrospective study. Patients were divided into three groups according to tertiles of GPR (low, n=119; middle, n=117; and high, n=118). To determine the relationship between GPR and prognosis, a logistic regression analysis was performed. The ability of GPR to predict the outcomes was evaluated by receiver operating characteristic (ROC) curve analysis. Two prediction models were established, and the likelihood ratio test (LRT) and the Akaike Information Criterion (AIC) were utilized for model comparison. Results. Among the 354 patients (age 62 [52, 74], 254/354 male) who were finally included in the analysis, those in the high GPR group had poor outcomes. Multivariate logistic regression analysis revealed that GPR was independently associated with the three outcomes, for ICU mortality (odds ratios OR=1.738, 95% confidence interval (CI): 1.221-2.474, P=0.002), hospital mortality (OR=1.6761.164-2.413, P=0.005), and unfavorable neurologic outcomes (OR=1.6231.121-2.351, P=0.010). The area under the ROC curve was 0.611 (95% Cl: 0.558-0.662) for ICU mortality, 0.600 (95% CI: 0.547-0.651) for hospital mortality, and 0.602 (95% CI: 0.549-0.653) for unfavorable neurologic outcomes. Further, the LRT analysis showed that compared with the model without GPR, the GPR-combined model had a higher likelihood ratio chi 2 score and smaller AIC. Conclusion. GPR, as an inflammatory indicator, was independently associated with outcomes after CA. GPR is helpful in estimating the clinical outcomes of patients with CA."

基金机构：National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31871182]

基金资助正文：The authors sincerely thank Enrica Iesu et al. for sharing their data. This study was supported by the National Natural Science Foundation of China (Grant No. 31871182).