P-Selectin Glycoprotein Ligand 1: A Potential HIV-1 Therapeutic Target

作者全名："Zaongo, Silvere D.; Liu, Yanqiu; Harypursat, Vijay; Song, Fangzhou; Xia, Huan; Ma, Ping; Chen, Yaokai"

作者地址："[Zaongo, Silvere D.; Liu, Yanqiu; Harypursat, Vijay; Chen, Yaokai] Chongqing Publ Hlth Med Ctr, Div Infect Dis, Chongqing, Peoples R China; [Zaongo, Silvere D.; Song, Fangzhou] Chongqing Med Univ, Basic Med Coll, Chongqing, Peoples R China; [Xia, Huan; Ma, Ping] Tianjin Second Peoples Hosp, Dept Infect Dis, Tianjin, Peoples R China; [Xia, Huan; Ma, Ping] Nankai Univ, Sch Med, Tianjin, Peoples R China"

通信作者："Chen, YK (corresponding author), Chongqing Publ Hlth Med Ctr, Div Infect Dis, Chongqing, Peoples R China.; Ma, P (corresponding author), Tianjin Second Peoples Hosp, Dept Infect Dis, Tianjin, Peoples R China.; Ma, P (corresponding author), Nankai Univ, Sch Med, Tianjin, Peoples R China."

来源：FRONTIERS IN IMMUNOLOGY

ESI学科分类：IMMUNOLOGY

WOS号：WOS:000687959800001

JCR分区：Q1

影响因子：7.3

年份：2021

卷号：12

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：P-selectin glycoprotein ligand 1; HIV; therapeutic target; infection; inflammation

摘要："Antiretroviral therapy (ART), which is a life-long therapeutic option, remains the only currently effective clinical method to treat HIV-1 infection. However, ART may be toxic to vital organs including the liver, brain, heart, and kidneys, and may result in systemic complications. In this context, to consider HIV-1 restriction factors from the innate immune system to explore novel HIV therapeutics is likely to be a promising investigative strategy. In light of this, P-selectin glycoprotein ligand 1 (PSGL-1) has recently become the object of close scrutiny as a recognized cell adhesion molecule, and has become a major focus of academic study, as researchers believe that PSGL-1 may represent a novel area of interest in the research inquiry into the field of immune checkpoint inhibition. In this article, we review PSGL-1's structure and functions during infection and/or inflammation. We also outline a comprehensive review of its role and potential therapeutic utility during HIV-1 infection as published in contemporary academic literature."

基金机构：Medical Research Project of Chongqing Municipal Science and Technology Bureau and Health Commission [2020GDRC004]; Key Medical Research Project of Chongqing Municipal Science and Technology Bureau and Health Commission [2019ZDXM012]

基金资助正文：This work was funded by the Medical Research Project of Chongqing Municipal Science and Technology Bureau and Health Commission (grant number 2020GDRC004) and the Key Medical Research Project of Chongqing Municipal Science and Technology Bureau and Health Commission (grant number 2019ZDXM012).