"Fibrinogen, fibrin degradation products and risk of sarcopenia"

作者全名："Chen, Jin-Liang; Chen, Dong-Mei; Luo, Cheng; Sun, Yue; Zhao, Yu-Xing; Huang, Chang-Quan; Zhao, Ke-Xiang; Xiao, Qian"

作者地址："[Chen, Jin-Liang; Luo, Cheng; Sun, Yue; Zhao, Yu-Xing; Huang, Chang-Quan; Zhao, Ke-Xiang; Xiao, Qian] Chongqing Med Univ, Dept Geriatr, Affiliated Hosp 1, Friendship Rd 1, Chongqing 400016, Peoples R China; [Chen, Dong-Mei] Karamay Cent Hosp, Dept Resp & Crit Care Med, 67 Zhunger Rd, Karamay City 834000, Xinjiang, Peoples R China"

通信作者："Xiao, Q (corresponding author), Chongqing Med Univ, Dept Geriatr, Affiliated Hosp 1, Friendship Rd 1, Chongqing 400016, Peoples R China."

来源：CLINICAL NUTRITION

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000689303600004

JCR分区：Q1

影响因子：6.3

年份：2021

卷号：40

期号：8

开始页：4830

结束页：4837

文献类型：Article

关键词：Fibrinogen; Fibrin degradation products; Sarcopenia; Inflammation; Elderly

摘要："Background & aims: Increasing data suggests that chronic low-grade inflammation plays an important role on development of sarcopenia. The present study was designed to identify the association between fibrinogen, fibrin degradation products (FDP) and sarcopenia risk in hospitalized old patients. Methods: A total of 437 patients were enrolled in this cross-sectional study (148 with sarcopenia and 289 without sarcopenia). Sarcopenia was diagnosed according to the Asian Working Group for Sarcopenia (AWGS) 2019 criteria. Body composition, grip strength and gait speed were performed to participants. Fibrinogen, FDP levels were measured. Logistic regression analyses were carried out to assess the association between fibrinogen and sarcopenia, between FDP and sarcopenia, respectively. Results: Compared to non-sarcopenic patients, fibrinogen and FDP levels were found to be higher in the sarcopenic group (3.07 g/L vs 2.79 g/L, 1.75 mu g/mL vs 1.00 mu g/mL, respectively, p < 0.05). Multiple linear regression analysis showed a significant negative association between fibrinogen and gait speed (beta: -0.164, p = 0.008), and muscle strength (beta: -0.231, p < 0.001). Multivariable logistic regression analysis showed that fibrinogen and FDP were independently associated with sarcopenia (odds ratio 1.32 [95% confidence interval 1.03, 1.70], p = 0.009; odds ratio 1.07 [95% confidence interval 1.01, 1.19], p = 0.049, respectively). ROC curve revealed that the cutoff values of fibrinogen and FDP to predict sarcopenia risk were 2.54 g/L and 1.15 mu g/mL, respectively. Conclusions: In hospitalized old patients, serum fibrinogen and FDP levels are elevated in sarcopenia patients than those without sarcopenia. Fibrinogen and FDP are associated with sarcopenia in a concentration-dependent manner. (C) 2021 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved."

基金机构：National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81801385]

基金资助正文：This work was financially supported by grants from National Natural Science Foundation of China (No. 81801385).