Sorting nexins: role in the regulation of blood pressure

作者全名："Huang, Juan; Tiu, Andrew C.; Jose, Pedro A.; Yang, Jian"

作者地址："[Huang, Juan; Yang, Jian] Chongqing Med Univ, Affiliated Hosp 3, Dept Clin Nutr, Chongqing 401120, Peoples R China; [Tiu, Andrew C.] Einstein Med Ctr Philadelphia, Dept Med, Philadelphia, PA USA; [Jose, Pedro A.] George Washington Univ, Sch Med & Hlth Sci, Dept Med, Div Renal Dis & Hypertens, Washington, DC 20037 USA; [Jose, Pedro A.] George Washington Univ, Sch Med & Hlth Sci, Dept Physiol & Pharmacol, Washington, DC 20037 USA"

通信作者："Yang, J (通讯作者)，Chongqing Med Univ, Affiliated Hosp 3, Dept Clin Nutr, Chongqing 401120, Peoples R China."

来源：FEBS JOURNAL

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:000734285600001

JCR分区：Q2

影响因子：5.4

年份：2022

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Review; Early Access

关键词：antihypertensive treatment; blood pressure; hypertension; sorting nexin; trafficking

摘要："Sorting nexins (SNXs) are a family of proteins that regulate cellular cargo sorting and trafficking, maintain intracellular protein homeostasis, and participate in intracellular signaling. SNXs are also important in the regulation of blood pressure via several mechanisms. Aberrant expression and dysfunction of SNXs participate in the dysregulation of blood pressure. Genetic studies show a correlation between SNX gene variants and the response to antihypertensive drugs. In this review, we summarize the progress in SNX-mediated regulation of blood pressure, discuss the potential role of SNXs in the pathophysiology and treatment of hypertension, and propose novel strategies for the medical therapy of hypertension."

基金机构："National Natural Science Foundation of China [81770425, 82070442]; Key Program of The Third Affiliated Hospital of Chongqing Medical University [KY19024]; National Institutes of Health [5R01DK039308, 5P01HL074940, R01DK119652]"

基金资助正文："The work was funded by grants from the National Natural Science Foundation of China (81770425, 82070442), Key Program of The Third Affiliated Hospital of Chongqing Medical University (KY19024), and the National Institutes of Health (5R01DK039308, 5P01HL074940, and R01DK119652)."