"Radiological classification, gene-mutation status, and surgical prognosis of synchronous multiple primary lung cancer"

作者全名："Huo, Ji-wen; Luo, Tian-you; He, Xiao-qun; Gong, Jun-wei; Lv, Fa-jin; Li, Qi"

作者地址："[Huo, Ji-wen; Luo, Tian-you; He, Xiao-qun; Gong, Jun-wei; Lv, Fa-jin; Li, Qi] Chongqing Med Univ, Dept Radiol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China"

通信作者："Li, Q (通讯作者)，Chongqing Med Univ, Dept Radiol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China."

来源：EUROPEAN RADIOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000739814700006

JCR分区：Q1

影响因子：5.9

年份：2022

卷号：32

期号：6

开始页：4264

结束页：4274

文献类型：Article

关键词：Lung neoplasms; Computed tomography; Mutation; Prognosis

摘要："Objective To investigate the radiological classification, gene-mutation status, and surgical prognosis of synchronous multiple primary lung cancer (sMPLC). Methods From January 2013 to October 2019, 192 consecutive patients with sMPLC were investigated. The clinical, CT, molecular, and pathological features of all patients were analyzed. Furthermore, the prognosis of 89 patients who only underwent surgical resection was evaluated. Results Among 192 patients, all lesions pathologically confirmed or highly suspected as tumors based on radiological findings were retrospectively analyzed, and the CT findings of sMPLC were classified into three types: (I) all lesions manifested as solid nodules/masses (14.06%, 27/192), (II) all lesions manifested as subsolid nodules/masses (43.23%, 83/192), and (III) tumor lesions manifested as a combination of >= 2 of the following patterns: solid nodules/masses, subsolid nodules/ masses, cystic airspace, and focal consolidation (42.71%, 82/192). For 252 tumors undergoing epidermal growth factor receptor (EGFR)-mutation testing, the EGFR-mutation rate was higher in subsolid tumors than that in solid tumors (p < 0.05). Among 19 patients with all tumors undergoing surgery and driver- gene testing, genetic heterogeneity was prevalent among the multiple tumors (63.16%,12/19). The highest clinical stage of non-I, ipsilateral distribution of tumors, and CT classification of I indicated a poor prognosis for patients with sMPLC (all p < 0.05). Conclusion Subsolid lesions are the most common presentation of sMPLC. Genetic heterogeneity in driver mutations among sMPLC may be present. Prognosis in patients with sMPLC is determined by the highest clinical TNM stage, distribution, and radiological classification among the multiple tumors."

基金机构："Chongqing Science and Technology Commission [cstc2017jcyjAX0281, cstc2016shmsztzx10002]; Chongqing Health and Family Planning Commission [2022MSXM147]"

基金资助正文：This study has received funding from the Chongqing Science and Technology Commission (cstc2017jcyjAX0281 and cstc2016shmsztzx10002) and Chongqing Health and Family Planning Commission (2022MSXM147) of China.