Does famine exposure in early life modify risks of metabolic diseases in Chinese adults? Evidence based on YiduCloud clinic data

作者全名："Zhang, Yong; Xu, Xiaoyang; Rahmani, Jamal; Ryan, Paul M."

作者地址："[Zhang, Yong; Xu, Xiaoyang] Chongqing Med Univ, Sch Publ Hlth & Hlth Management, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China; [Xu, Xiaoyang] Hosp Chongqing Med Univ, Chongqing 400016, Peoples R China; [Rahmani, Jamal] Shahid Beheshti Univ Med Sci, Dept Community Nutr, Fac Nutr & Food Technol, Natl Nutr & Food Technol Res Inst, Tehran, Iran; [Ryan, Paul M.] Univ Coll Cork, Sch Med, Cork, Ireland"

通信作者："Zhang, Y (通讯作者)，Chongqing Med Univ, Sch Publ Hlth & Hlth Management, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China."

来源：INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000740209700001

JCR分区：Q4

影响因子：0.9

年份：2022

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期号：　

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文献类型：Article; Early Access

关键词：Famine; Metabolic disease; Fetal origins hypothesis; Big clinic data

摘要："Background Due to inconclusive findings of Chinese famine exposure to risk of metabolic diseases, we investigate the relationship between famine exposure in early stage of life and risk of metabolic diseases in middle-aged adults in southwest China by using the novel YiduCloud big clinic data. Methods In this retrospective study, electronic clinic records of those born between 1949 and 1978, which covers the years of the Chinese Famine in 1959-1961, were retrieved from the YiduCloud big database which has encompassed seven teaching hospitals from 1999 to the present day. Patients' gender, birth year, admitted year, height, and weight were extracted, and diagnosis of hypertension (HTN) and diabetes mellitus (DM) were identified. Relationships between birth year and risk of HTN and DM were analyzed by using linear regression. Height, weight, and BMI (body mass index) were also compared by birth year with linear regression analysis. Results More than 360 thousand patients born in year from 1949 to 1978 were included. Those born at the first year of famine experienced longer after birth exposure did not show increased risks of HTN and DM with lower average height, weight and BMI than born year predicted values, whereas those born in the second or third year of famine followed by shorter after birth exposure actually had increased risks of HTN and DM with higher average height, weight and BMI than born year predicted values. All of the above mentioned differences were more pronounced in male than those in female. Conclusion People who were born in years of the Chinese Famine had different risks of metabolic diseases like HTN and DM in middle ages. Selection of persistent undernutrition pressure after birth and in time replenishment of food with acquired catch-up growth after birth may help explain those different risks of metabolic diseases in adults who were born in early or later famine years. Anyway, malnutrition exposure in early stage of life alone does not likely change too much the risk of metabolic diseases. This study provides some details to fetal origins hypothesis of metabolic diseases."

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