Abnormal connectivity model of raphe nuclei with sensory-associated cortex in Parkinson's disease with chronic pain

作者全名："Shen, Yalian; Wang, Juan; Peng, Juan; Wu, Xiaolin; Chen, Xiaocui; Liu, Jinjin; Wei, Min; Zou, Dezhi; Han, Yu; Wang, Anran; Cheng, Oumei"

作者地址："[Shen, Yalian; Wang, Juan; Wu, Xiaolin; Chen, Xiaocui; Liu, Jinjin; Wei, Min; Zou, Dezhi; Han, Yu; Cheng, Oumei] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing 400016, Peoples R China; [Shen, Yalian] Yubei Dist Peoples Hosp, Dept Neurol, Chongqing 401120, Peoples R China; [Peng, Juan; Wang, Anran] Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, Chongqing 400016, Peoples R China"

通信作者："Cheng, OM (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing 400016, Peoples R China.; Wang, AR (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, Chongqing 400016, Peoples R China."

来源：NEUROLOGICAL SCIENCES

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:000740410400001

JCR分区：Q2

影响因子：3.3

年份：2022

卷号：43

期号：5

开始页：3175

结束页：3185

文献类型：Article

关键词：Parkinson's disease; Chronic pain; Raphe nuclei; Functional connectivity; 5-hydroxytryptamine

摘要："Background and Objective There are indicates that raphe nuclei may be involved in the occurrence of chronic pain in Parkinson's disease (PD). In the study, we investigated the functional connectivity pattern of raphe nuclei in Parkinson's disease with chronic pain (PDP) to uncover its possible pathophysiology. Methods Fifteen PDP, who suffered from pain, lasted longer than 3 months, sixteen Parkinson's disease patients with no pain (nPDP) and eighteen matched normal health controls (NCs) were recruited. All subjects completed the King's Parkinson's Pain Scale (KPPS) besides Parkinson-related scale and demographics. We performed a seed-based resting-state analysis of functional magnetic resonance imaging to explore whole-brain functional connectivity of the raphe nuclei. Multiple regression model was used to explore the related factors of pain including disease duration, disease severity, Hamilton Depression Rating Scale, age, sex, levodopa equivalent dose and the strength of network functional connectivity. Results Compared with the nPDP, the PDP group showed stronger functional connectivity between raphe nuclei and pain-related brain regions, including parietal lobe, insular lobe, cingulum cortex and prefrontal cortex, and the functional connectivity values of those areas were significantly positively correlated with KPPS independent of the clinical variables. Compared with NCs, the combined PD groups showed decreased functional connectivity including prefrontal cortex and cingulum cortex. Conclusions Abnormal functional connectivity model of raphe nuclei may be partly involved in pathophysiological mechanism of pain in PD."

基金机构："National Natural Science Foundation of China [81871002, 81471334, 81100981]; National Key Clinical Specialties Construction Program of China"

基金资助正文："This research was supported by the National Natural Science Foundation of China (No. 81871002, 81471334, 81100981) and the National Key Clinical Specialties Construction Program of China. rostroventromedial medulla are involved in pain processing."