IR780 loaded hollow MnO2 nanoparticles for dual-mode imaging and enhanced photodynamic therapy of oral squamous cell carcinoma

作者全名："Pan, Wei; He, Ye; He, Mengdong; Wang, Fei; Qiu, Lihua"

作者地址："[Pan, Wei; He, Ye; He, Mengdong; Wang, Fei; Qiu, Lihua] Chongqing Med Univ, Dept Oral & Maxillofacial Surg, Stomatol Hosp, Chongqing 401147, Peoples R China; [Pan, Wei; He, Mengdong; Wang, Fei; Qiu, Lihua] Chongqing Med Univ, Chongqing Municipal Key Lab Oral Biomed Engn High, Chongqing 401147, Peoples R China; [Pan, Wei; He, Mengdong; Wang, Fei] Chongqing Med Univ, Chongqing Key Lab Ultrasound Mol Imaging, Chongqing 400010, Peoples R China"

通信作者："Pan, W; Qiu, LH (通讯作者)，Chongqing Med Univ, Dept Oral & Maxillofacial Surg, Stomatol Hosp, Chongqing 401147, Peoples R China.; Pan, W; Qiu, LH (通讯作者)，Chongqing Med Univ, Chongqing Municipal Key Lab Oral Biomed Engn High, Chongqing 401147, Peoples R China.; Pan, W (通讯作者)，Chongqing Med Univ, Chongqing Key Lab Ultrasound Mol Imaging, Chongqing 400010, Peoples R China."

来源：BIOCELL

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:000744170800003

JCR分区：Q3

影响因子：1.2

年份：2022

卷号：46

期号：4

开始页：1079

结束页：1088

文献类型：Article

关键词：Endogenous oxygen generation; Tumor hypoxia; Multimodal imaging; Photodynamic therapy; Oral squamous cell carcinoma

摘要："Photodynamic therapy (PDT) has emerged as a novel therapeutic modality for cancer treatment, but its therapeutic efficacy is severely limited by the hypoxic tumor microenvironment (TME). Here we designed an innovative multifunctional nano-platform which consists of a hollow MnO2 shell and internal photosensitizer IR780. It is not only used for multimodal imaging of oral squamous cell carcinoma (OSCC), but also for adjustment hypoxic TME to enhance cancer treatment. Hollow MnO2 can promote decomposition of tumor endogenous H2O2 to relieve tumor hypoxia, thereby enhancing the effect of photodynamic therapy. Photosensitizer IR780 generates singlet oxygen under laser irradiation to kill tumor cells, playing photodynamic effect, can also act as the contrast agents for photoacoustic and fluorescence multiple imaging, providing potential imaging capability for cancer therapeutic guidance and monitoring. Our research results in this article show that HMnO2-1R780 nanocomposite exhibits good biocompatibility and nontoxicity, strong PA/FL imaging contrast, excellent oxygen production capacity and outstanding photodynamic therapy effect. This finding provides a new idea for multimodal imaging-guided nanotherapy for OSCC."

基金机构：Chongqing Social Livelihood Science and Technology Innovation Project [cstc2016shmszx00010]; Science and Technology Research Project of Chongqing Education Commission [KJ1600231]; Program for Innovation Team Building at Institutions of Higher Education in Chongqing [CXTDG201602006]

基金资助正文："The present study was funded by the Chongqing Social Livelihood Science and Technology Innovation Project (Grant No. cstc2016shmszx00010), the Science and Technology Research Project of Chongqing Education Commission (Grant No. KJ1600231) and the Program for Innovation Team Building at Institutions of Higher Education in Chongqing (Grant No. CXTDG201602006)."