Quantitative susceptibility mapping shows lower brain iron content in children with attention-deficit hyperactivity disorder

作者全名："Tang, Shilong; Zhang, Guanping; Ran, Qiying; Nie, Lisha; Liu, Xianfan; Pan, Zhengxia; He, Ling"

作者地址："[Tang, Shilong; Zhang, Guanping; Ran, Qiying; Liu, Xianfan; He, Ling] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders,Chongqin, Dept Radiol,Minist Educ,Key Lab Child Dev & Disor, Minist Educ Key Lab Child Dev & Disorders,Childre, Chongqing, Peoples R China; [Pan, Zhengxia] Chongqing Med Univ, Dept Cardiovasc & Thorac Surg, Childrens Hosp, Chongqing, Peoples R China; [Nie, Lisha] MR Res China, GE Healthcare, Beijing, Peoples R China"

通信作者："He, L (通讯作者)，Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders,Chongqin, Dept Radiol,Minist Educ,Key Lab Child Dev & Disor, Minist Educ Key Lab Child Dev & Disorders,Childre, Chongqing, Peoples R China."

来源：HUMAN BRAIN MAPPING

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:000749620100001

JCR分区：Q1

影响因子：4.8

年份：2022

卷号：43

期号：8

开始页：2495

结束页：2502

文献类型：Article

关键词：attention-deficit hyperactivity disorder; brain; iron; magnetic resonance imaging; quantitative susceptibility mapping

摘要："To investigate the feasibility of quantitative susceptibility mapping in children with attention-deficit hyperactivity disorder (ADHD), 53 children with ADHD aged 5-16 years were prospectively selected as the study group and 49 healthy children matched with age and gender were selected as the control group. All children underwent magnetic resonance imaging conventional sequence, 3D-T1, and enhanced T2*-weighted magnetic resonance angiography (ESWAN) sequence scanning. The iron content of brain regions was obtained through software postprocessing, and the iron content of brain regions of children with ADHD and healthy children was compared and analyzed to find out the characteristics of the iron content of brain regions of children with ADHD. The iron content in frontal lobe, globus pallidus, caudate nucleus, substantia nigra, putamen, and hippocampus of children with ADHD was lower than that of healthy children (p < .05). There was no significant difference in the content of iron in the left and right brain regions of children with ADHD (p > .05). The volume of frontal lobe and hippocampus of children with ADHD was lower than that of healthy children (p < .05). Iron content in brain areas such as globus pallidus, caudate nucleus, hippocampus, and putamen could distinguish children with ADHD (Area under curve [AUC] > 0.5, p < .05). Quantitative susceptibility mapping showed decreased iron content in some brain regions of children with ADHD."

基金机构：Chongqing Municipal Education Commission [KJQN202000425]; National Clinical Research Center for Child Health and Disorders [NCRCCHD-2021-YP-07]; GE Healthcare

基金资助正文："Chongqing Municipal Education Commission, Grant/Award Number: KJQN202000425; National Clinical Research Center for Child Health and Disorders, Grant/Award Number: NCRCCHD-2021-YP-07; GE Healthcare"