Age-related risk for second breast cancer and gynecological malignant neoplasms after differentiated thyroid cancer

作者全名："Zhao, Xianlan; Yang, Guangrong; Zhang, Weina; Dong, Qiang; Yang, Qiao"

作者地址："[Zhao, Xianlan] Peoples Hosp Honghuagang Dist, Zunyi, Guizhou, Peoples R China; [Yang, Guangrong] Chongqing Med Univ, Affiliated Hosp 1, Qijiang Hosp, Dept Oncol, Qijiang, Peoples R China; [Zhang, Weina] 941st Hosp PLA Joint Logist Support Force, Dept Crit Care Med, Xining, Peoples R China; [Dong, Qiang] Chongqing Med Univ, Affiliated Hosp 1, Qijiang Hosp, Dept Gen Med, Qijiang, Peoples R China; [Yang, Qiao] 941st Hosp PLA Joint Logist Support Force, Dept Ultrasound, Xining, Peoples R China"

通信作者："Yang, Q (通讯作者)，941st Hosp PLA Joint Logist Support Force, Dept Ultrasound, Xining, Peoples R China."

来源：ENDOCRINE

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:000751212200001

JCR分区：Q2

影响因子：3.7

年份：2022

卷号：76

期号：2

开始页：385

结束页：394

文献类型：Article

关键词：Differentiated thyroid cancer; Second breast cancer; Second gynecological malignant neoplasms; Female; Age; Risk factor

摘要："Purpose In this study, we aimed to investigate the age-related risk of second breast cancer (SBC) and second gynecological malignant neoplasms (SGMNs) in female differentiated thyroid cancer (DTC) survivors by utilizing the Surveillance, Epidemiology, and End Results (SEER) database. Methods A total number of 55,622 female DTC patients were identified between 1975 and 2016, including 2168 patients who developed SBC and SGMNs. The Fine and Gray model was used to calculate the cumulative incidence and sub-distribution hazards ratios (SHR). Poisson regression analysis was employed to calculate the relative risk (RR) and standardized incidence ratio (SIR). Kaplan-Meier survival and log-rank test analyses were also performed. Results The overall 40-year cumulative incidence of SBC and SGMNs was 18.9%. Their incidence in the adolescent and young adults (AYA) group increased slowly in the first 30 years, but then was rapidly elevated in the last decade. It increased gradually in the middle-aged adults group and in the first 25 years in the older adults group, but it scarcely increased thereafter. Both the middle-aged adults (adjusted SHR, 2.09; RR, 1.76) and the older adults (adjusted SHR, 1.32; RR, 1.58) groups had higher risks of developing combined SBC and SGMNs than the AYA group. The risks increased mainly in the early latency period. The three groups also had higher SIRs than the US general population. Besides, the best survival after SBC and SGMNs was observed in the AYA group. Conclusions Age was an independent risk factor for SBC and SGMNs incidences among female DTC survivors."

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