"Near-Infrared II Nanoadjuvant-Mediated Chemodynamic, Photodynamic, and Photothermal Therapy Combines Immunogenic Cell Death with PD-L1 Blockade to Enhance Antitumor Immunity"

作者全名："Xiang, Qinyanqiu; Yang, Chao; Luo, Yuanli; Liu, Fan; Zheng, Jun; Liu, Weiwei; Ran, Haitao; Sun, Yang; Ren, Jianli; Wang, Zhigang"

作者地址："[Xiang, Qinyanqiu] Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, Chongqing 400010, Peoples R China; [Yang, Chao] Univ Chinese Acad Sci, Chongqing Gen Hosp, Dept Radiol, Chongqing 400010, Peoples R China; [Luo, Yuanli; Liu, Fan; Zheng, Jun; Liu, Weiwei; Ran, Haitao; Sun, Yang; Ren, Jianli; Wang, Zhigang] Chongqing Med Univ, Affiliated Hosp 2, Chongqing Key Lab Ultrasound Mol Imaging, Chongqing 400010, Peoples R China; [Luo, Yuanli; Liu, Fan; Zheng, Jun; Liu, Weiwei; Ran, Haitao; Sun, Yang; Ren, Jianli; Wang, Zhigang] Chongqing Med Univ, Affiliated Hosp 2, Dept Ultrasound, Chongqing 400010, Peoples R China"

通信作者："Wang, ZG (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Chongqing Key Lab Ultrasound Mol Imaging, Chongqing 400010, Peoples R China.; Wang, ZG (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Ultrasound, Chongqing 400010, Peoples R China."

来源：SMALL

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:000753553500001

JCR分区：Q1

影响因子：13.3

年份：2022

卷号：18

期号：13

开始页：　

结束页：　

文献类型：Article

关键词：immune checkpoint blockade; immunogenic cell death; iron tungsten oxide; multimodal imaging; multimodal theranostics

摘要："The efficacy of immune checkpoint inhibition in inducing death of cancer cells is affected by the immunosuppressive ""cold"" tumor microenvironment, which results in a poor response by the patient's antitumor immune system. However, the immunomodulatory effects of immunogenic cell death in response to irritation by heat energy and reactive oxygen species (ROS) can switch the tumor microenvironment from ""cold"" to ""hot."" This study has developed a nanoadjuvant for immune therapy using iron tungsten oxide (FeWOx)-based nanosheets with surface PEGylation (FeWOx-PEG). This FeWOx-PEG nanoadjuvant serves as a chemodynamic reagent via the Fenton reaction and acts as a photosensitizer for photodynamic and photothermal therapy under near-infrared II laser irradiation; however, it could also be used to augment tumor-infiltrating T-cells and provoke a systemic antitumor immune response by combining the immunogenic cell death triggered by ROS and photothermal therapy with the immune checkpoint blockade. This research demonstrates that application of the FeWOx-PEG nanoadjuvant under the guidance of magnetic resonance/computed tomography/photoacoustic imaging can eliminate the primary tumor and suppress the growth of distant tumors."

基金机构：National Natural Science Foundation of China [82172092]; Chongqing Science & Technology Commission [cstc2019jscx-dxwtBX0004]

基金资助正文：This work was supported by the National Natural Science Foundation of China (No. 82172092) and Chongqing Science & Technology Commission (No. cstc2019jscx-dxwtBX0004).