Blood urea nitrogen to serum albumin ratio as a new prognostic indicator in critical patients with chronic heart failure

作者全名："Lin, Zebin; Zhao, Yipin; Xiao, Li; Qi, Chenlu; Chen, Qinwei; Li, Yin"

作者地址："[Lin, Zebin; Zhao, Yipin; Xiao, Li; Qi, Chenlu; Chen, Qinwei] Chongqing Med Univ, Dept Gen Med, Affiliated Hosp 2, 76 Linjiang Rd, Chongqing 400010, Peoples R China; [Li, Yin] Chongqing Med Univ, Dept Hepatobiliary Surg, Affiliated Hosp 2, Chongqing, Peoples R China"

通信作者："Chen, QW (通讯作者)，Chongqing Med Univ, Dept Gen Med, Affiliated Hosp 2, 76 Linjiang Rd, Chongqing 400010, Peoples R China."

来源：ESC HEART FAILURE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000753876700001

JCR分区：Q2

影响因子：3.8

年份：2022

卷号：9

期号：2

开始页：1360

结束页：1369

文献类型：Article

关键词：Critical chronic heart failure; Blood urea nitrogen; Serum albumin; Ratio; Risk factor

摘要："Aims Chronic heart failure (CHF) is often a common comorbidity in critically ill patients admitted to the intensive care unit (ICU) and carries an extremely poor prognosis. The study aimed to investigate the relationship between the blood urea nitrogen to serum albumin ratio (BAR) and the prognosis of patients with CHF admitted to the ICU. Methods and results This retrospective cohort study included 1545 critically ill patients with CHF as a diagnosed comorbidity admitted to the ICU deposited in the MIMIC-III database, of whom 90 day all-cause mortality was 27.6% (n = 427) and in-hospital mortality was 17.3% (n = 267). The results of multiple logistic regression analysis indicated that BAR is an independent risk factor for in-hospital mortality in critically ill patients with CHF [compared with BAR <= 0.83; 0.83 < BAR <= 1.24: odds ratio (OR) 2.647, 95% confidence interval (CI) 1.797-3.900, P < 0.001; BAR >= 1.24: OR 3.628, 95% CI 2.604-5.057, P COX regression analysis found a relationship between BAR and all-cause mortality at 90 day follow-up (0.83 < BAR <= 1.24: OR 1.948, 95% CI 1.259-3.014, P < 0.003; BAR >= 1.24: OR 1.807, 95% CI 1.154-2.830, P < 0.01; BAR <= 0.83 as a reference). Kaplan-Meier curves also showed similar results as well (P < 0.001). The areas under the receiver operating characteristic curves for predicting in-hospital mortality and 90 day all-cause mortality were 0.622 and 0.647, respectively. Conclusions BAR is an independent risk factor for in-hospital mortality and 90 day mortality in critically ill patients with CHF admitted to the ICU."

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