Systematic Influence of Circulating Bilirubin Levels on Osteoporosis

作者全名："Zhao, Jinqiu; Zhang, Muzi; Quan, Zhengxue; Deng, Liang; Li, Yongguo; He, Bin"

作者地址："[Zhao, Jinqiu; Li, Yongguo] Chongqing Med Univ, Dept Infect Dis, Affiliated Hosp 1, Chongqing, Peoples R China; [Zhang, Muzi; Quan, Zhengxue; He, Bin] Chongqing Med Univ, Dept Orthoped, Affiliated Hosp 1, Chongqing, Peoples R China; [Deng, Liang] Chongqing Med Univ, Dept Gastroenterol, Affiliated Hosp 1, Chongqing, Peoples R China"

通信作者："Li, YG (通讯作者)，Chongqing Med Univ, Dept Infect Dis, Affiliated Hosp 1, Chongqing, Peoples R China.; Deng, L (通讯作者)，Chongqing Med Univ, Dept Gastroenterol, Affiliated Hosp 1, Chongqing, Peoples R China."

来源：FRONTIERS IN ENDOCRINOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000758804300001

JCR分区：Q2

影响因子：5.2

年份：2021

卷号：12

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：osteoporosis; circulating bilirubin levels; BMD; fracture; Mendelian randomization study

摘要："Observational studies report some association between circulating bilirubin levels and osteoporosis, but it is unknown if this association is causal or confounded. In this two-sample Mendelian randomization (MR) study, we included a large genome-wide association study (GWAS) associated with total bilirubin levels among 317,639 people, a large meta-analysis to identify genetic variants associated with bone mineral density (BMD) estimated by heel quantitative ultrasound (eBMD) among 426,824 individuals and fracture among 1.2 million individuals. The results revealed that circulating bilirubin levels had no causal influence on eBMD (beta-estimate: 0.004, 95% confidence interval [CI]: -0.019 to 0.028, SE:0.012, P-value=0.705) or the risk of fracture (beta-estimate: -0.009, 95% CI: -0.035 to 0.017, SE:0.013, P-value=0.488), which were both confirmed by multiple sensitivity analyses. Our results confirm that circulating bilirubin levels have no causal role in eBMD or the incidence of fracture, indicating that circulating bilirubin levels is unlikely to be a causal risk factor for osteoporosis or fracture."

基金机构：Chongqing Yuzhong Nature Science Foundation of China [2018114]; National Natural Science Foundation of China [82070626]; Natural Science Foundation of Chongqing [cstc2019jcyj-msxmX0836]

基金资助正文："This study was funded by Chongqing Yuzhong Nature Science Foundation of China (Grant No. 2018114), National Natural Science Foundation of China (82070626) and Natural Science Foundation of Chongqing (cstc2019jcyj-msxmX0836)."