"Functionalized Mn3O4 Nanosheets with Photothermal, Photodynamic, and Oxidase-Like Activities Triggered by Low-Powered Near-Infrared Light for Synergetic Combating Multidrug-Resistant Bacterial Infections"

作者全名："Zhang, Xinwen; Min, Yuanhong; Zhang, Qi; Wu, Shiyue; Fu, Wensheng; Wu, Jiangling; Li, Ming; Wang, Yi; Zhang, Pu"

作者地址："[Zhang, Xinwen; Zhang, Qi; Li, Ming; Zhang, Pu] Chongqing Med Univ, Coll Pharm, Chongqing Res Ctr Pharmaceut Engn, Chongqing 400016, Peoples R China; [Min, Yuanhong; Wu, Shiyue; Fu, Wensheng; Wang, Yi] Chongqing Normal Univ, Coll Chem, Engn Res Ctr Biotechnol Act Subst, Chongqing Key Lab Green Synth & Applicat,Minist E, Chongqing 401331, Peoples R China; [Wu, Jiangling] Chongqing Med Univ, Dept Clin Lab, Univ Town Hosp, Chongqing 401331, Peoples R China"

通信作者："Zhang, P (通讯作者)，Chongqing Med Univ, Coll Pharm, Chongqing Res Ctr Pharmaceut Engn, Chongqing 400016, Peoples R China.; Wang, Y (通讯作者)，Chongqing Normal Univ, Coll Chem, Engn Res Ctr Biotechnol Act Subst, Chongqing Key Lab Green Synth & Applicat,Minist E, Chongqing 401331, Peoples R China."

来源：ADVANCED HEALTHCARE MATERIALS

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:000761230800001

JCR分区：Q1

影响因子：10

年份：2022

卷号：11

期号：12

开始页：　

结束页：　

文献类型：Article

关键词：antibacterial; manganese oxide; nanozymes; photothermal; reactive oxygen species; synergetic therapy

摘要："Multidrug-resistant (MDR) pathogenic bacterial infections have become a major danger to public health. Synergetic therapy through multiple approaches is more powerful than the respective one alone, but has been rarely achieved in defeating MDR bacterial infections so far. Herein, indocyanine green-functionalized Mn3O4 nanosheets are engineered as an efficient and safe antibacterial agent with photothermal, photodynamic, and oxidase-like activities, which display powerful ability in treating MDR bacterial infections. Therein, photothermal and photodynamic activities can be triggered by a single low-powered near-infrared laser (808 nm, 0.33 W cm(-2)), resulting in the generation of localized hyperthermia (photothermal conversion efficiency, 67.5%) and singlet oxygen. Meanwhile, oxidase-like activity of this material further leads to the generation of hydroxyl radical as well as superoxide radical. Sheet-like structure with rough surfaces make them tends to adhere on bacterial surface and thus damage membrane system as well as influence bacterial metabolism. As a result, Gram-positive and Gram-negative bacteria can both be eradicated. Animal experiments further indicate that the functionalized Mn3O4 nanosheets can effectively treat methicillin-resistant Staphylococcus aureus-infected wounds through the triple synergetic therapy. Moreover, toxicity evaluation in vitro and in vivo has proved the superior biosafety of this material, which is promising to apply in clinical anti-infective therapy."

基金机构："National Natural Science Foundation of China [21775014, 81972020]; Scientific and Technological Innovation Project for Construction of Double City Economic Circle in Chengdu-Chongqing Region [KJCXZD2020024]; Chongqing Innovation Research Group Project [CXQT21015]; Chongqing High-level Personnel of Special Support Program; Chongqing Talent Program"

基金资助正文："X.Z., Y.M., and Q.Z. contributed equally to this work. This work was supported by the National Natural Science Foundation of China (nos. 21775014 and 81972020), Scientific and Technological Innovation Project for Construction of Double City Economic Circle in Chengdu-Chongqing Region (no. KJCXZD2020024), and Chongqing Innovation Research Group Project (no. CXQT21015). Y.W. was also sponsored by the Chongqing High-level Personnel of Special Support Program. P.Z. and W.F. were also sponsored by the Chongqing Talent Program."