Recent advances in engineering iron oxide nanoparticles for effective magnetic resonance imaging

作者全名："Zhao, Zhenghuan; Li, Muyao; Zeng, Jie; Huo, Linlin; Liu, Kun; Wei, Ruixue; Ni, Kaiyuan; Gao, Jinhao"

作者地址："[Zhao, Zhenghuan; Li, Muyao; Zeng, Jie; Huo, Linlin] Chongqing Med Univ, Coll Basic Med Sci, Chongqing 400016, Peoples R China; [Zhao, Zhenghuan; Liu, Kun; Gao, Jinhao] Xiamen Univ, State Key Lab Phys Chem Solid Surfaces, Key Lab Chem Biol Fujian Prov, Coll Chem & Chem Engn, Xiamen 361005, Fujian, Peoples R China; [Zhao, Zhenghuan; Liu, Kun; Gao, Jinhao] Xiamen Univ, Dept Chem Biol, Coll Chem & Chem Engn, Xiamen 361005, Fujian, Peoples R China; [Wei, Ruixue] Zhengzhou Univ, Dept Cerebrovasc Dis, Affiliated Hosp 2, Zhengzhou 450052, Henan, Peoples R China; [Ni, Kaiyuan] MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02142 USA"

通信作者："Zhao, ZH (通讯作者)，Chongqing Med Univ, Coll Basic Med Sci, Chongqing 400016, Peoples R China.; Gao, JH (通讯作者)，Xiamen Univ, State Key Lab Phys Chem Solid Surfaces, Key Lab Chem Biol Fujian Prov, Coll Chem & Chem Engn, Xiamen 361005, Fujian, Peoples R China.; Gao, JH (通讯作者)，Xiamen Univ, Dept Chem Biol, Coll Chem & Chem Engn, Xiamen 361005, Fujian, Peoples R China."

来源：BIOACTIVE MATERIALS

ESI学科分类：　

WOS号：WOS:000761393600002

JCR分区：Q1

影响因子：18.9

年份：2022

卷号：12

期号：　

开始页：214

结束页：245

文献类型：Article

关键词：Iron oxide nanoparticles; Improved relaxation; Dual-modal contrast imaging; Environment responsive imaging; Strcture engineering

摘要："Iron oxide nanoparticle (IONP) with unique magnetic property and high biocompatibility have been widely used as magnetic resonance imaging (MRI) contrast agent (CA) for long time. However, a review which comprehensively summarizes the recent development of IONP as traditional T-2 CA and its new application for different modality of MRI, such as T-1 imaging, simultaneous T-2/T-1 or MRI/other imaging modality, and as environment responsive CA is rare. This review starts with an investigation of direction on the development of highperformance MRI CA in both T-2 and T-1 modal based on quantum mechanical outer sphere and Solomon-Bloembergen-Morgan (SBM) theory. Recent rational attempts to increase the MRI contrast of IONP by adjusting the key parameters, including magnetization, size, effective radius, inhomogeneity of surrounding generated magnetic field, crystal phase, coordination number of water, electronic relaxation time, and surface modification are summarized. Besides the strategies to improve r(2) or r(1) values, strategies to increase the in vivo contrast efficiency of IONP have been reviewed from three different aspects, those are introducing second imaging modality to increase the imaging accuracy, endowing IONP with environment response capacity to elevate the signal difference between lesion and normal tissue, and optimizing the interface structure to improve the accumulation amount of IONP in lesion. This detailed review provides a deep understanding of recent researches on the development of high-performance IONP based MRI CAs. It is hoped to trigger deep thinking for design of next generation MRI CAs for early and accurate diagnosis."

基金机构："National Natural Science Foundation of China [81601607, 81971609]; Chongqing High-level Personnel of Special Support Program (Youth Top-notch Talent) [CQYC201905077]; Creative Research Group of CQ University [CXQT21017]"

基金资助正文："This work was supported by the National Natural Science Foundation of China (81601607 and 81971609), Chongqing High-level Personnel of Special Support Program (Youth Top-notch Talent CQYC201905077), and Creative Research Group of CQ University (CXQT21017)."