Research progress on RNA-binding proteins in breast cancer

作者全名："Zhang, Wenzhu; Liu, Linlin; Zhao, Shengdi; Chen, Liang; Wei, Yuxian; Chen, Wenlin; Ge, Fei"

作者地址："[Zhang, Wenzhu; Zhao, Shengdi; Chen, Liang; Ge, Fei] Kunming Med Univ, Dept Breast Surg, Affiliated Hosp 1, 295 Xichang Rd, Kunming 650032, Yunnan, Peoples R China; [Zhang, Wenzhu; Zhao, Shengdi] Kunming Med Univ, Sch Clin Med 1, Kunming 650500, Yunnan, Peoples R China; [Liu, Linlin] Kunming Med Univ, Sch Forens Med, Kunming 650500, Yunnan, Peoples R China; [Wei, Yuxian] Chongqing Med Univ, Dept Endocrine Breast Surg, Affiliated Hosp 1, Chongqing 400016, Peoples R China; [Chen, Wenlin] Kunming Med Univ, Dept Breast Surg 3, Affiliated Hosp 3, 519 Kunzhou Rd, Kunming 650118, Yunnan, Peoples R China"

通信作者："Ge, F (通讯作者)，Kunming Med Univ, Dept Breast Surg, Affiliated Hosp 1, 295 Xichang Rd, Kunming 650032, Yunnan, Peoples R China.; Chen, WL (通讯作者)，Kunming Med Univ, Dept Breast Surg 3, Affiliated Hosp 3, 519 Kunzhou Rd, Kunming 650118, Yunnan, Peoples R China."

来源：ONCOLOGY LETTERS

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000761717700001

JCR分区：Q3

影响因子：2.9

年份：2022

卷号：23

期号：4

开始页：　

结束页：　

文献类型：Review

关键词：breast cancer; RNA-binding protein; research progress

摘要："Breast cancer is the most common malignancy among women, and the abnormal regulation of gene expression serves an important role in its occurrence and development. However, the molecular mechanisms underlying gene expression are highly complex and heterogeneous, and RNA-binding proteins (RBPs) are among the key regulatory factors. RBPs bind targets in an environment-dependent or environment-independent manner to influence mRNA stability and the translation of genes involved in the formation, progression, metastasis and treatment of breast cancer. Due to the growing interest in these regulators, the present review summarizes the most influential studies concerning RBPs associated with breast cancer to elucidate the role of RBPs in breast cancer and to assess how they interact with other key pathways to provide new molecular targets for the diagnosis and treatment of breast cancer."

基金机构："National Natural Science Foundation of China [82060543, 82060538]; Yunnan Fundamental Research Projects [202101AT070347]"

基金资助正文：The present study was supported by the National Natural Science Foundation of China (grant nos. 82060543 and 82060538) and the Yunnan Fundamental Research Projects (grant no. 202101AT070347).