Pre-treatment circulating reproductive hormones levels predict pathological and survival outcomes in breast cancer submitted to neoadjuvant chemotherapy

作者全名："Lan, Ailin; Jin, Yudi; Wang, Yu; Wang, Yihua; Ding, Nan; Dai, Yuran; Jiang, Linshan; Tang, Zhenrong; Peng, Yang; Liu, Shengchun"

作者地址："[Lan, Ailin; Jin, Yudi; Wang, Yu; Wang, Yihua; Ding, Nan; Dai, Yuran; Jiang, Linshan; Tang, Zhenrong; Peng, Yang; Liu, Shengchun] Chongqing Med Univ, Affiliated Hosp 1, Dept Endocrine & Breast Surg, 1 Youyi Rd, Chongqing 400016, Peoples R China"

通信作者："Liu, SC (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Endocrine & Breast Surg, 1 Youyi Rd, Chongqing 400016, Peoples R China."

来源：INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000763878700001

JCR分区：Q3

影响因子：3.3

年份：2022

卷号：27

期号：5

开始页：899

结束页：910

文献类型：Article

关键词：Breast cancer; Reproductive hormones; Neoadjuvant therapy; Testosterone; Progesterone; Follicle-stimulating hormone

摘要："Purpose This study aimed to evaluate the correlation of pre-treatment circulating reproductive hormones levels with pathological and survival outcomes in breast cancer patients received neoadjuvant chemotherapy (NAC). Methods Information from 196 premenopausal and 137 postmenopausal breast cancer patients who received NAC were retrospectively analyzed. Treatment response to NAC, with odds ratios (OR) and 95% confidence intervals (95% CI) was estimated using logistic regression adjusted for key confounders. Survival outcomes with hazard ratios (HR) and 95% CI were estimated using Cox regression adjusted for key confounders. The Kaplan-Meier method was applied in the survival analysis. Results Premenopausal patients with lower testosterone levels (OR = 0.996, 95% CI 0.992-0.999, P = 0.026), and postmenopausal patients with higher follicle-stimulating hormone (FSH) levels (OR = 1.045, 95% CI 1.014-1.077, P = 0.005) were likely to achieve pathological complete response (pCR). In multivariate survival analysis, the lowest tertile (T) progesterone was associated with worse overall survival (OS) in premenopausal patients (T2 vs T1, HR = 0.113, 95% CI 0.013-0.953, P = 0.045; T3 vs T1, HR = 0.109, 95% CI 0.013-0.916, P = 0.041). Premenopausal patients with the lowest tertile progesterone exhibited worse 3-year OS compared with those with higher tertiles (72.9% vs 97.4%, log-rank, P = 0.007). Conclusion Pre-treatment testosterone and FSH are significant independent predictors for pCR to NAC in premenopausal and postmenopausal patients, respectively. Low progesterone levels are correlated with worse OS in premenopausal patients. These findings may provide a theoretical basis for pre-operative endocrine therapy combined with NAC in breast cancer."

基金机构："National Natural Science Foundation of China [81772979, 81472658]"

基金资助正文："This work was funded by the National Natural Science Foundation of China (No. 81772979 and 81472658). The funding source had no role in the study design, data collection, data analysis, data interpretation, or the writing of the report."