Efficacy and safety of transcutaneous auricular vagus nerve stimulation combined with conventional rehabilitation training in acute stroke patients: a randomized controlled trial conducted for 1 year involving 60 patients

作者全名："Li, Jia-Ni; Xie, Chen-Chen; Li, Chang-Qing; Zhang, Gui-Fang; Tang, Hao; Jin, Chuan-Na; Ma, Jing-Xi; Wen, Lan; Zhang, Ke-Ming; Niu, Ling-Chuan"

作者地址："[Li, Jia-Ni; Xie, Chen-Chen; Li, Chang-Qing; Zhang, Gui-Fang; Tang, Hao; Jin, Chuan-Na; Niu, Ling-Chuan] Chongqing Med Univ, Affiliated Hosp 2, Dept Neurol, Chongqing, Peoples R China; [Ma, Jing-Xi] Univ Chinese Acad Sci, Chongqing Gen Hosp, Dept Neurol, Chongqing, Peoples R China; [Ma, Jing-Xi] Chongqing Key Lab Neurodegenerat Dis, Chongqing, Peoples R China; [Wen, Lan] Sichuan Univ, West China Hosp, Dept Neurol, Chengdu, Sichuan, Peoples R China; [Zhang, Ke-Ming] Chongqing Med & Pharmaceut Coll, Clin Coll, Chongqing, Peoples R China"

通信作者："Niu, LC (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Neurol, Chongqing, Peoples R China."

来源：NEURAL REGENERATION RESEARCH

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:000766445300037

JCR分区：Q2

影响因子：6.1

年份：2022

卷号：17

期号：8

开始页：1809

结束页：1813

文献类型：Article

关键词：activity of daily living; early stage treatment; emotional disorder; limb dysfunction; neural regeneration; randomized controlled clinical trial; rehabilitation; safety of treatment; stroke; transcutaneous auricular-vagus nerve stimulation

摘要："Transcutaneous auricular vagus nerve stimulation (ta-VNS) is a novel noninvasive treatment for stroke that directly stimulates the peripheral auricular branch of the vagus nerve. There have been recent reports that ta-VNS combined with conventional rehabilitation training promotes the recovery of neurological function of patients with acute stroke. However, these were small-sample-sized studies on the recovery of neurological function in patients after percutaneous vagus nerve stimulation in the subacute and chronic phases after stroke. This double-blinded randomized controlled trial involved 60 acute ischemic or hemorrhagic stroke patients aged 18-80 years who received treatment in the Second Affiliated Hospital of Chongqing Medical University. The subjects were randomly assigned to receive ta-VNS or sham ta-VNS combined with conventional rehabilitation training. The follow-up results over 1 year revealed that ta-VNS combined with conventional rehabilitation training greatly improved the recovery of motor and sensory functions and emotional responses compared with sham ta-VNS combined with conventional rehabilitation training. There were no obvious side effects. These findings suggest that ta-VNS combined with conventional rehabilitation training for the treatment of acute ischemic or hemorrhagic stroke patients is safe and effective."

基金机构："Medical Scientific Research Project of Chongqing Municipal Health Commission of China [2018ZDXM022, 2019MSXM017, 2020MSXM106]; Chongqing General Hospital of China [2019ZDXM03]"

基金资助正文："This work was supported by the Medical Scientific Research Project of Chongqing Municipal Health Commission of China, Nos. 2018ZDXM022, 2019MSXM017 and 2020MSXM106; and a grant from Chongqing General Hospital of China, No. 2019ZDXM03 (all to LCN and JXM)."