Extracellular vesicles from helicobacter pylori-infected cells and helicobacter pylori outer membrane vesicles in atherosclerosis

作者全名："Qiang, Liming; Hu, Jianguo; Tian, Mingyuan; Li, Yu; Ren, Chao; Deng, Yi; Jiang, Yuan"

作者地址："[Qiang, Liming] Sichuan Univ, West China Guangan Hosp, Dept Gastroenterol, Guangan, Peoples R China; [Hu, Jianguo] Chongqing Med Univ, Affiliated Hosp 2, Dept Obstet & Gynecol, Chongqing, Peoples R China; [Tian, Mingyuan] Chongqing Med Univ, Affiliated Hosp 2, Dept Endocrinol, Chongqing, Peoples R China; [Li, Yu; Ren, Chao; Deng, Yi; Jiang, Yuan] Chengdu Med Coll, Affiliated Hosp 1, Clin Med Coll, Chengdu, Peoples R China"

通信作者："Jiang, Y (通讯作者)，Chengdu Med Coll, Clin Med Coll, Chengdu, Peoples R China.; Jiang, Y (通讯作者)，Chengdu Med Coll, Affiliated Hosp 1, Chengdu, Peoples R China."

来源：HELICOBACTER

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000766774700005

JCR分区：Q2

影响因子：4.4

年份：2022

卷号：27

期号：2

开始页：　

结束页：　

文献类型：Review

关键词：atherosclerosis; extracellular vesicles; extragastric diseases; Helicobacter pylori; outer membrane vesicles

摘要："Background: The role of H. pylori infection has been reported in various extragastric diseases, particularly, the correlation between H. pylori and atherosclerosis (AS) have received lots of attention. Some scholars demonstrated that the presence of H. pylori-specific DNA in the sclerotic plaques of atheromatous patients provides biological evidences, with indicating that H. pylori infection is a potential factor of AS. However, the underlying mechanism of H. pylori or their products cross the epithelial barriers to enter the blood circulation remains unclear. Recent studies have shown that the extracellular vesicles (EVs) derived from H. pylori-infected gastric epithelial cells encapsulated H. pylori virulence factor cytotoxin-associated gene A (CagA) and existed in the blood samples of patients or mice, which indicating that they can carry CagA into the blood circulation. Based on these findings, some researchers proposed a hypothesis that H. pylori is involved in the pathogenesis of AS via EVs-based mechanisms. In addition, outer membrane vesicles (OMVs) serve as transport vehicles to deliver H. pylori virulence factors to epithelial cells. It is necessary to discuss the role of H. pylori OMVs in the development of AS. Objectives: This review will focus on the correlation between H. pylori infection and AS and tried to unveil the possible role of EVs from H. pylori-infected cells and H. pylori OMVs in the pathogenesis of AS, with a view to providing help in refining our knowledge in this aspect. Methods: All of information included in this review was retrieved from published studies on H. pylori infection in AS. Results: H. pylori infection may be an atherosclerotic risk factor and drives researchers to reevaluate the role of H. pylori in the pathogenesis of AS. Some findings proposed a new hypothesis that H. pylori may be involved in the pathogenesis of AS through EVs-based mechanisms. Besides EVs from H. pylori-infected cells, whether H. pylori OMVs may play some role in the pathogenesis of AS is still remain unclear. Conclusion: Existing epidemiological and clinical evidence had shown that there is a possible association between H. pylori and AS. However, except for the larger randomized controlled trials, more basic research about EVs from H. pylori-infected cells and H. pylori OMVs is the need of the hour to unveil the possible role of H. pylori infection in the pathogenesis of AS."

基金机构：National Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81801389]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2019M652857]; Research project of the Science and Technology Department of Sichuan province [2021YJ0217]; Funds of High level talents of the First Affiliated Hospital of Chengdu Medical College [CYFY-GQ06]; Research Project of Sichuan Applied Psychology Research Center of Chengdu Medical College [CSXL-202A13]

基金资助正文："This work was supported by the grants from the National Science Foundation of China (81801389), China Postdoctoral Science Foundation Grant (2019M652857), Research project of the Science and Technology Department of Sichuan province (2021YJ0217), Funds of High level talents of the First Affiliated Hospital of Chengdu Medical College (CYFY-GQ06), and Research Project of Sichuan Applied Psychology Research Center of Chengdu Medical College (CSXL-202A13)"