A pH-responsive hyaluronic acid hydrogel for regulating the inflammation and remodeling of the ECM in diabetic wounds

作者全名："Jia, Yile; Zhang, Xianhui; Yang, Weihu; Lin, Chuanchuan; Tao, Bailong; Deng, Zhiwen; Gao, Pengfei; Yang, Yulu; Cai, Kaiyong"

作者地址："[Jia, Yile; Zhang, Xianhui; Yang, Weihu; Lin, Chuanchuan; Deng, Zhiwen; Gao, Pengfei; Yang, Yulu; Cai, Kaiyong] Chongqing Univ, Coll Bioengn, Key Lab Biorheol Sci & Technol, Minist Educ, Chongqing 400044, Peoples R China; [Tao, Bailong] Chongqing Med Univ, Affiliated Hosp 1, Chongqing 400016, Peoples R China; [Cai, Kaiyong] Chongqing Key Lab Soft Matter Mat Chem & Funct Mf, Chongqing 400715, Peoples R China"

通信作者："Yang, WH; Cai, KY (通讯作者)，Chongqing Univ, Coll Bioengn, Key Lab Biorheol Sci & Technol, Minist Educ, Chongqing 400044, Peoples R China.; Cai, KY (通讯作者)，Chongqing Key Lab Soft Matter Mat Chem & Funct Mf, Chongqing 400715, Peoples R China."

来源：JOURNAL OF MATERIALS CHEMISTRY B

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:000768209400001

JCR分区：Q2

影响因子：7

年份：2022

卷号：10

期号：15

开始页：2875

结束页：2888

文献类型：Article

关键词：　

摘要："Diabetes is a universal disease in the world. In the wounds of diabetic individuals, chronic inflammation and an inefficient fibrogenic process hinder the formation and deposition of the ECM, which delays the process of wound healing. To reconstruct the ECM of a diabetic patient's wound, in this work, we designed a pH-responsive ""Double H-bonds"" (hydrogen bond and hydrazone bond) hyaluronic acid-collagen hydrogel. This hydrogel can be self-gelled quickly in neutral and alkaline environments. But the weakly acidic inflammatory environment of diabetic wounds may accelerate the degradation of the hydrogel and the release of metformin. The in vitro results showed that the hydrogel can enhance the adhesion and infiltration of fibroblasts while inhibiting the growth of macrophages. Meanwhile, metformin could be released and polarize macrophages from M1 to M2, thereby accelerating the migration of fibroblasts and the production of collagen in a high glucose environment. The in vivo results proved that this hydrogel could remodel the ECM in diabetic mice wounds."

基金机构："National Natural Science Foundation of China [32071334, 51825302, 21734002]; Natural Science Foundation of Chongqing [cstc2021jcyj-cxttX0002, cstc2019jscx-msxmX0160]"

基金资助正文："This work was financially supported by the National Natural Science Foundation of China (32071334, 51825302 & 21734002), and the Natural Science Foundation of Chongqing (cstc2021jcyj-cxttX0002 and cstc2019jscx-msxmX0160)."