A Natural Hydrogel with Prohealing Properties Enhances Tendon Regeneration
作者全名："Dang, Ruyi; Chen, Liling; Sefat, Farshid; Li, Xian; Liu, Shilin; Yuan, Xulei; Ning, Xiaoqiao; Zhang, Yu Shrike; Ji, Ping; Zhang, Ximu"
作者地址："[Dang, Ruyi; Chen, Liling; Li, Xian; Liu, Shilin; Yuan, Xulei; Ning, Xiaoqiao; Ji, Ping; Zhang, Ximu] Chongqing Med Univ, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing 401174, Peoples R China; [Dang, Ruyi; Chen, Liling; Li, Xian; Liu, Shilin; Yuan, Xulei; Ning, Xiaoqiao; Ji, Ping; Zhang, Ximu] Chongqing Med Univ, Chongqing Municipal Key Lab Oral Biomed Engn High, Chongqing 401174, Peoples R China; [Dang, Ruyi; Chen, Liling; Li, Xian; Liu, Shilin; Yuan, Xulei; Ning, Xiaoqiao; Ji, Ping; Zhang, Ximu] Chongqing Med Univ, Stomatol Hosp, Chongqing 401174, Peoples R China; [Sefat, Farshid] Univ Bradford, Interdisciplinary Res Ctr Polymer Sci & Technol P, Bradford BD7 1DP, W Yorkshire, England; [Sefat, Farshid] Univ Bradford, Sch Engn, Biomed & Elect Engn Dept, Bradford BD7 1DP, W Yorkshire, England; [Zhang, Yu Shrike] Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Div Engn Med, Cambridge, MA 02139 USA"
通信作者："Ji, P; Zhang, XM (通讯作者)，Chongqing Med Univ, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing 401174, Peoples R China.; Ji, P; Zhang, XM (通讯作者)，Chongqing Med Univ, Chongqing Municipal Key Lab Oral Biomed Engn High, Chongqing 401174, Peoples R China.; Ji, P; Zhang, XM (通讯作者)，Chongqing Med Univ, Stomatol Hosp, Chongqing 401174, Peoples R China.; Zhang, YS (通讯作者)，Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Div Engn Med, Cambridge, MA 02139 USA."
来源：SMALL
ESI学科分类：MATERIALS SCIENCE
WOS号：WOS:000770486300001
JCR分区：Q1
影响因子：13.3
年份：2022
卷号：
期号：
开始页：
结束页：
文献类型：Article; Early Access
关键词：andrias davidianus; antiadhesion; antibacterial properties; hydrogels; tendon healing
摘要："Tendon regeneration and reduction of peritendinous adhesion remain major clinical challenges. This study addresses these challenges by adopting a unique hydrogel derived from the skin secretion of Andrias davidianus (SSAD) and taking advantage of its biological effects, adhesiveness, and controllable microstructures. The SSAD-derived hydrogel contains many cytokines, which could promote tendon healing. In vitro, leach liquid of SSAD powder could promote tendon stem/progenitor cells migration. In vivo, the SSAD-derived hydrogel featuring double layers possesses strong adhesiveness and could reconnect ruptured Achilles tendons of Sprague-Dawley rats without suturing. The intimal SSAD-derived hydrogel, with a pore size of 241.7 +/- 21.0 mu m, forms the first layer of the hydrogel to promote tendon healing, and the outer layer SSAD-derived hydrogel, with a pore size of 3.3 +/- 1.4 mu m, reducing peritendinous adhesion by serving as a dense barrier. Additionally, the SSAD-derived hydrogel exhibits antioxidant and antibacterial characteristics, which further contribute to the reduction of peritendinous adhesion. In vivo studies suggest that the SSAD-derived hydrogel reduces peritendinous adhesion, increases collagen fiber deposition, promotes cell proliferation, and improves the biomechanical properties of the regenerated tendons, indicating better functional restoration. The SSAD-derived bilayer hydrogel may be a feasible biomaterial for tendon repair in the future."
基金机构："National Natural Science Foundation of China [32070826, 31871464]; Chongqing Science and Health Joint Medical project [2020GDRC017]; UK Research Councils (RCUK) China-UK Science Bridges Program through the Medical Research Council; Fundamental Research Funds for the Central Universities"
基金资助正文："This work was financed by the National Natural Science Foundation of China (32070826 and 31871464), Chongqing Science and Health Joint Medical project (2020GDRC017) and the UK Research Councils (RCUK) China-UK Science Bridges Program through the Medical Research Council, and the Fundamental Research Funds for the Central Universities. Y.S.Z. was not supported by any of these funds."
