Impaired robust interhemispheric function integration of depressive brain from REST-meta-MDD database in China
作者全名："Deng, Ke; Yue, Ji-Hui; Xu, Jian; Ma, Ping-Ping; Chen, Xiao; Li, Le; Bai, Tong-Jian; Bo, Qi-Jing; Cao, Jun; Chen, Guan-Mao; Chen, Ning-Xuan; Chen, Wei; Cheng, Chang; Cui, Xi-Long; Duan, Jia; Fang, Yi-Ru; Gong, Qi-Yong; Guo, Wen-Bin; Hou, Zheng-Hua; Hu, Lan; Kuang, Li; Li, Feng; Li, Tao; Liu, Yan-Song; Liu, Zhe-Ning; Long, Yi-Cheng; Luo, Qing-Hua; Meng, Hua-Qing; Peng, Dai-Hui; Qiu, Hai-Tang; Qiu, Jiang; Shi, Yu-Shu; Si, Tian-Mei; Tang, Yan-Qin; Wang, Fei; Wang, Kai; Wang, Li; Wang, Xiang; Wang, Ying; Wu, Xiao-Ping; Wu, Xin-Ran; Xie, Chun-Ming; Xie, Guang-Rong; Xie, Hai-Yan; Xie, Peng; Yang, Hong; Yang, Jian; Yao, Jia-Shu; Yao, Shu-Qiao; Yin, Ying-Ying; Yuan, Yong-Gui; Zhang, Ai-Xia; Zhang, Hong; Zhang, Ke-Rang; Zhang, Lei; Zhang, Zhi-Jun; Zhou, Ru-Bai; Zhou, Yi-Ting; Zhu, Jun-Juan; Zou, Chao-Jie; Zhou, Cong; Zuo, Xi-Nian; Yan, Chao-Gan; Xu, Xiu-Feng; Cheng, Yu-Qi"
作者地址："[Deng, Ke; Ma, Ping-Ping; Zou, Chao-Jie; Zhou, Cong; Xu, Xiu-Feng; Cheng, Yu-Qi] Kunming Med Univ, Dept Psychiat, Affiliated Hosp 1, 295 Xichang Rd, Kunming 650032, Yunnan, Peoples R China; [Deng, Ke] Jiaxing Univ, Dept Psychiat, Hosp Jiaxing 1, Jiaxing, Zhejiang, Peoples R China; [Deng, Ke] Jiaxing Univ, Affiliated Hosp 1, Jiaxing, Zhejiang, Peoples R China; [Yue, Ji-Hui] Sun Yat Sen Univ, Affiliated Hosp 5, Dept Psychiat, Zhuhai, Guangdong, Peoples R China; [Yue, Ji-Hui] Sun Yat Sen Univ, Affiliated Hosp 5, Res Ctr Mol Imaging, Zhuhai, Guangdong, Peoples R China; [Xu, Jian] Kunming Med Univ, Affiliated Hosp 1, Dept Rheumatol, Kunming, Yunnan, Peoples R China; [Ma, Ping-Ping] Fifth Peoples Hosp Zigong City, Zigong, Sichuan, Peoples R China; [Chen, Xiao; Li, Le; Chen, Ning-Xuan; Zhang, Lei; Zuo, Xi-Nian; Yan, Chao-Gan] Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China; [Chen, Xiao; Li, Le; Chen, Ning-Xuan; Zhang, Lei; Zuo, Xi-Nian; Yan, Chao-Gan] Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing, Peoples R China; [Bai, Tong-Jian; Wang, Kai] Anhui Med Univ, Hefei, Anhui, Peoples R China; [Bo, Qi-Jing; Li, Feng] Capital Med Univ, Beijing Anding Hosp, Beijing, Peoples R China; [Cao, Jun; Hu, Lan; Kuang, Li; Luo, Qing-Hua; Meng, Hua-Qing; Qiu, Hai-Tang] Chongqing Med Univ, Affiliated Hosp 1, Dept Psychiat, Chongqing, Peoples R China; [Chen, Guan-Mao; Wang, Ying] Jinan Univ, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China; [Chen, Wei; Yao, Jia-Shu] Zhejiang Univ, Sir Run Shaw Hosp, Dept Psychiat, Sch Med, Hangzhou, Zhejiang, Peoples R China; [Cheng, Chang; Guo, Wen-Bin; Liu, Zhe-Ning; Long, Yi-Cheng; Wang, Xiang; Xie, Guang-Rong; Yao, Shu-Qiao] Cent South Univ, Xiangya Hosp 2, Dept Psychiat, Changsha, Hunan, Peoples R China; [Cui, Xi-Long; Duan, Jia; Tang, Yan-Qin; Wang, Fei] China Med Univ, Affiliated Hosp 1, Dept Psychiat, Shenyang, Liaoning, Peoples R China; [Fang, Yi-Ru; Peng, Dai-Hui; Zhou, Ru-Bai; Zhu, Jun-Juan] Shanghai Jiao Tong Univ, Dept Psychiat, Sch Med, Shanghai, Peoples R China; [Gong, Qi-Yong] Sichuan Univ, Huaxi MR Res Ctr, Dept Radiol, West China Hosp, Chengdu, Sichuan, Peoples R China; [Gong, Qi-Yong] Sichuan Univ, Psychoradiol Res Unit, Chinese Acad Med Sci, West China Hosp, Chengdu, Sichuan, Peoples R China; [Hou, Zheng-Hua; Yin, Ying-Ying; Yuan, Yong-Gui] Southeast Univ, Zhongda Hosp, Sch Med, Dept Psychosomat & Psychiat, Nanjing, Jiangsu, Peoples R China; [Li, Tao; Zhou, Yi-Ting] Sichuan Univ Chengdu, West China Hosp, Mental Hlth Ctr, Chengdu, Sichuan, Peoples R China; [Liu, Yan-Song] Soochow Univ, Dept Clin Psychol, Suzhou Psychiat Hosp, Affiliated Guangji Hosp, Suzhou, Jiangsu, Peoples R China; [Qiu, Jiang; Wu, Xin-Ran] Southwest Univ, Fac Psychol, Chongqing, Peoples R China; [Shi, Yu-Shu; Yang, Hong] Zhejiang Univ, Affiliated Hosp 1, Coll Med, Dept Radiol, Hangzhou, Zhejiang, Peoples R China; [Si, Tian-Mei; Wang, Li] Peking Univ Sixth Hosp, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China; [Si, Tian-Mei; Wang, Li] Peking Univ, Key Lab Mental Hlth, Minist Hlth, Beijing, Peoples R China; [Wu, Xiao-Ping; Zhang, Hong] Xian Cent Hosp, Xian, Shaanxi, Peoples R China; [Xie, Chun-Ming; Zhang, Zhi-Jun] Southeast Univ, Dept Neurol, Affiliated ZhongDa Hosp, Nanjing, Jiangsu, Peoples R China; [Xie, Hai-Yan] Zhejiang Univ, Affiliated Hosp 4, Coll Med, Dept Psychiat, Hangzhou, Zhejiang, Peoples R China; [Xie, Peng] Chongqing Med Univ, Inst Neurosci, Chongqing, Peoples R China; [Xie, Peng] Chongqing Key Lab Neurobiol, Chongqing, Peoples R China; [Xie, Peng] Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing, Peoples R China; [Yang, Jian; Zhang, Ai-Xia] Xi An Jiao Tong Univ, Affiliated Hosp 1, Xian, Shaanxi, Peoples R China; [Zhang, Ke-Rang] Shanxi Med Univ, Hosp 1, Taiyuan, Shanxi, Peoples R China"
通信作者："Cheng, YQ (通讯作者)，Kunming Med Univ, Dept Psychiat, Affiliated Hosp 1, 295 Xichang Rd, Kunming 650032, Yunnan, Peoples R China."
来源：BIPOLAR DISORDERS
ESI学科分类：PSYCHIATRY/PSYCHOLOGY
WOS号：WOS:000770833000001
JCR分区：Q2
影响因子：5.4
年份：2022
卷号：
期号：
开始页：
结束页：
文献类型：Article; Early Access
关键词：functional connectivity (FC); functional homotopy (FH); interhemispheric function integration; major depressive disorder (MDD); resting-state functional magnetic resonance imaging (R-fMRI); voxel-mirrored homotopic connectivity (VMHC)
摘要："Background Recently, functional homotopy (FH) architecture, defined as robust functional connectivity (FC) between homotopic regions, has been frequently reported to be altered in MDD patients (MDDs) but with divergent locations. Methods In this study, we obtained resting-state functional magnetic resonance imaging (R-fMRI) data from 1004 MDDs (mean age, 33.88 years; age range, 18-60 years) and 898 matched healthy controls (HCs) from an aggregated dataset from 20 centers in China. We focused on interhemispheric function integration in MDDs and its correlation with clinical characteristics using voxel-mirrored homotopic connectivity (VMHC) devised to inquire about FH patterns. Results As compared with HCs, MDDs showed decreased VMHC in visual, motor, somatosensory, limbic, angular gyrus, and cerebellum, particularly in posterior cingulate gyrus/precuneus (PCC/PCu) (false discovery rate [FDR] q < 0.002, z = -7.07). Further analysis observed that the reduction in SMG and insula was more prominent with age, of which SMG reflected such age-related change in males instead of females. Besides, the reduction in MTG was found to be a male-special abnormal pattern in MDDs. VMHC alterations were markedly related to episode type and illness severity. The higher Hamilton Depression Rating Scale score, the more apparent VMHC reduction in the primary visual cortex. First-episode MDDs revealed stronger VMHC reduction in PCu relative to recurrent MDDs. Conclusions We confirmed a significant VMHC reduction in MDDs in broad areas, especially in PCC/PCu. This reduction was affected by gender, age, episode type, and illness severity. These findings suggest that the depressive brain tends to disconnect information exchange across hemispheres."
基金机构："National Natural Science Foundation of China [82060259, 81760296, 81660237]; Medical Leader Foundation of Yunnan Province [L2019011, L2019004]; Famous Doctors Project of Yunnan Province Plan [YNWR-MY-2018-040, YNWR-MY-2018-041]; Applied Basic Key Project of Yunnan Provincial Department of Science and Technology--Kunming Medical University Joint Foundation [2017FE468(-176)]"
基金资助正文："This work was supported by the National Natural Science Foundation of China (82060259, 81760296, 81660237), Medical Leader Foundation of Yunnan Province (L2019011, L2019004), Famous Doctors Project of Yunnan Province Plan (YNWR-MY-2018-040, YNWR-MY-2018-041), Applied Basic Key Project of Yunnan Provincial Department of Science and Technology--Kunming Medical University Joint Foundation (2017FE468(--176)). The data of this study were provided by the members of the REST--meta--MDD Consortium. The authors thank all those who assisted with this project."
