Resveratrol exhibits inhibition effects on osteogenic differentiation of aortic valve interstitial cells by interfering with the AKT pathway

作者全名："Jin, Yujia; Wang, Yue; Weng, Yaguang; Li, Xian; Huang, Qin; Liu, Yan; Xiang, Yi; Li, Xiaorong; Jiang, Peng; He, Wenhuan; Luo, Jiangqiao; Shi, Qiong"

作者地址："[Jin, Yujia; Wang, Yue; Weng, Yaguang; Huang, Qin; Liu, Yan; Xiang, Yi; Li, Xiaorong; Jiang, Peng; He, Wenhuan; Luo, Jiangqiao; Shi, Qiong] Chongqing Med Univ, MOE Key Lab Lab Med Diagnost, Dept Lab Med, Chongqing, Peoples R China; [Li, Xian] Chongqing Med Univ, Dept Pathol, Chongqing, Peoples R China"

通信作者："Shi, Q (通讯作者)，Chongqing Med Univ, MOE Key Lab Lab Med Diagnost, Dept Lab Med, Chongqing, Peoples R China."

来源：JOURNAL OF FUNCTIONAL FOODS

ESI学科分类：AGRICULTURAL SCIENCES

WOS号：WOS:000770860400002

JCR分区：Q1

影响因子：5.6

年份：2022

卷号：91

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Calcific aortic valve disease; Resveratrol; Osteogenic differentiation; Valve interstitial cells

摘要："Resveratrol is a natural active ingredient found in many plants and has a protective effect on cardiovascular diseases. However, it has not been reported that whether resveratrol can inhibit calcific aortic valve disease (CAVD). In this study, we want to explore the effect and mechanism of resveratrol on the osteogenic differentiation of valve interstitial cells(VICs).We first found that the expression of osteogenic markers in calcified human aortic valve. Western blotting, ALP staining and Alizarin red S staining showed that under osteogenic medium (OM) treatment, resveratrol can inhibit VICs from expressing osteogenic markers, reduce ALP content and calcium Nodule formation. Mechanistically, resveratrol can inhibit the activation of the AKT/Smad1/5/8 pathway induced by OM. We selected the AKT pathway for verification and determined that resveratrol inhibited the osteogenic differentiation of VICs by inhibiting the AKT pathway. Collectively, resveratrol may become a potential natural drug for the treatment of CAVD."

基金机构：National Natural Science Foundation of China [NSCF 81672103]; Chongqing Natural Science Foundation [cstc2021jcyj-msxmX0269]

基金资助正文："Acknowledgements This work was supported by the National Natural Science Foundation of China (grant Number:NSCF 81672103) , and the Chongqing Natural Science Foundation (grant number:cstc2021jcyj-msxmX0269) ."