Serum bile acid response to oral glucose is attenuated in patients with early type 2 diabetes and correlates with 2-hour plasma glucose in individuals without diabetes

作者全名："Wang, Xuyi; Chen, Chang; Xie, Cong; Huang, Weikun; Young, Richard L.; Jones, Karen L.; Horowitz, Michael; Rayner, Christopher K.; Sun, Zilin; Wu, Tongzhi"

作者地址："[Wang, Xuyi; Xie, Cong; Huang, Weikun; Young, Richard L.; Jones, Karen L.; Horowitz, Michael; Rayner, Christopher K.; Wu, Tongzhi] Univ Adelaide, Adelaide Med Sch, Adelaide, SA, Australia; [Wang, Xuyi; Xie, Cong; Huang, Weikun; Young, Richard L.; Jones, Karen L.; Horowitz, Michael; Rayner, Christopher K.; Wu, Tongzhi] Univ Adelaide, Ctr Res Excellence CRE Translating Nutr Sci Good, Adelaide, SA, Australia; [Wang, Xuyi] Southeast Univ, Dept Clin Nutr, Nanjing, Peoples R China; [Chen, Chang] Chongqing Med Univ, Inst Life Sci, Chongqing, Peoples R China; [Young, Richard L.] South Australian Hlth & Med Res Inst, Lifelong Hlth Theme, Nutr Diabet & Gut Hlth, Adelaide, SA, Australia; [Jones, Karen L.; Horowitz, Michael; Wu, Tongzhi] Royal Adelaide Hosp, Endocrine & Metab Unit, Adelaide, SA, Australia; [Rayner, Christopher K.] Royal Adelaide Hosp, Dept Gastroenterol & Hepatol, Adelaide, SA, Australia; [Sun, Zilin] Southeast Univ, Zhongda Hosp, Sch Med, Inst Diabet,Dept Endocrinol, Nanjing, Peoples R China"

通信作者："Wu, TZ (通讯作者)，Univ Adelaide, Level 6,Adelaide Hlth & Med Sci AHMS Bldg, Adelaide, SA 5000, Australia.; Sun, ZL (通讯作者)，87 Dingjiaqiao, Nanjing 210009, Peoples R China."

来源：DIABETES OBESITY & METABOLISM

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000771828900001

JCR分区：Q1

影响因子：5.8

年份：2022

卷号：24

期号：6

开始页：1132

结束页：1142

文献类型：Article

关键词：bile acids; fibroblast growth factor-19; glucagon-like peptide-1; postprandial glycaemia; type 2 diabetes

摘要："Aim To determine the serum bile acid (BA) response to 75-g oral glucose in individuals without diabetes, and whether this is attenuated in patients with 'early' type 2 diabetes (T2D) and related to the glycaemic response at 2 hours in either group. Methods Forty newly diagnosed, treatment-naive Han Chinese T2D subjects and 40 age-, gender-, and body mass index-matched controls without T2D ingested a 75-g glucose drink after an overnight fast. Plasma glucose and serum concentrations of total and individual BAs, fibroblast growth factor-19 (FGF-19), total glucagon-like peptide-1 (GLP-1), and insulin, were measured before and 2 hours after oral glucose. Results Fasting total BA levels were higher in T2D than control subjects (P < .05). At 2 hours, the BA profile exhibited a shift from baseline in both groups, with increases in conjugated BAs and/or decreases in unconjugated BAs. There were increases in total BA and FGF-19 levels in control (both P < .05), but not T2D, subjects. Plasma glucose concentrations at 2 hours related inversely to serum total BA levels in control subjects (r = -0.42, P = .006). Total GLP-1 and the insulin/glucose ratio were increased at 2 hours in both groups, and the magnitude of the increase was greater in control subjects. Conclusions The serum BA response to a 75-g oral glucose load is attenuated in patients with 'early' T2D, as is the secretion of FGF-19 and GLP-1, while in individuals without T2D it correlates with 2-hour plasma glucose levels. These observations support a role for BAs in the regulation of postprandial glucose metabolism."

基金机构："University of Adelaide, as part of the Wiley The University of Adelaide agreement via the Council of Australian University Librarians; WOA Institution: The University of Adelaide; Blended DEAL: CAUL [2022]"

基金资助正文："Open access publishing facilitated by The University of Adelaide, as part of the Wiley The University of Adelaide agreement via the Council of Australian University Librarians. WOA Institution: The University of Adelaide. Blended DEAL: CAUL 2022."