A prophylactic effect of aluminium-based adjuvants against respiratory viruses via priming local innate immunity

作者全名:"Wang, Xin; Yin, Xiaochen; Zhang, Boya; Liu, Chenfeng; Lin, Yahua; Huang, Xiaofen; Li, Yufang; Shen, Chenguang; Zheng, Weibin; Fu, Guofeng; Chen, Junyu; Wen, Yanling; Zhang, Wei; Pan, Bo-Sheng; Fang, Mujin; Zheng, Zizheng; Zhang, Zheng; Yuan, Quan; Fu, Guo; Li, Shaowei; Zhang, Jun; Chen, Yixin; Xia, Ningshao; Zhao, Qinjian"

作者地址:"[Wang, Xin; Yin, Xiaochen; Zhang, Boya; Lin, Yahua; Huang, Xiaofen; Li, Yufang; Shen, Chenguang; Chen, Junyu; Zhang, Wei; Fang, Mujin; Zheng, Zizheng; Yuan, Quan; Li, Shaowei; Zhang, Jun; Chen, Yixin; Xia, Ningshao; Zhao, Qinjian] Xiamen Univ, Sch Publ Hlth, Natl Inst Diagnost & Vaccine Dev Infect Dis, State Key Lab Mol Vaccinol & Mol Diagnost, Xiamen, Peoples R China; [Wang, Xin; Wen, Yanling; Zhang, Zheng] Southern Univ Sci & Technol, Natl Clin Res Ctr Infect Dis, Inst Hepatol, Shenzhen Peoples Hosp 3, Shenzhen, Peoples R China; [Wang, Xin; Wen, Yanling; Zhang, Zheng] Southern Univ Sci & Technol, Affiliated Hosp 2, Sch Med, Shenzhen, Peoples R China; [Zheng, Weibin; Fu, Guofeng; Fu, Guo] Xiamen Univ, Sch Life Sci, Xiamen, Peoples R China; [Liu, Chenfeng] Anhui Med Univ, Sch Life Sci, Dept Cell Biol, Hefei, Peoples R China; [Zhao, Qinjian] Chongqing Med Univ, Coll Pharm, Chongqing, Peoples R China; [Pan, Bo-Sheng] Reverie Labs, Cambridge, MA USA"

通信作者:"Wang, X; Chen, YX; Xia, NS; Zhao, QJ (通讯作者),Xiamen Univ, Sch Publ Hlth, Natl Inst Diagnost & Vaccine Dev Infect Dis, State Key Lab Mol Vaccinol & Mol Diagnost, Xiamen, Peoples R China.; Wang, X (通讯作者),Southern Univ Sci & Technol, Natl Clin Res Ctr Infect Dis, Inst Hepatol, Shenzhen Peoples Hosp 3, Shenzhen, Peoples R China.; Wang, X (通讯作者),Southern Univ Sci & Technol, Affiliated Hosp 2, Sch Med, Shenzhen, Peoples R China.; Zhao, QJ (通讯作者),Chongqing Med Univ, Coll Pharm, Chongqing, Peoples R China."

来源:EMERGING MICROBES & INFECTIONS

ESI学科分类:MICROBIOLOGY

WOS号:WOS:000773723600001

JCR分区:Q1

影响因子:13.2

年份:2022

卷号:11

期号:1

开始页:914

结束页:925

文献类型:Article

关键词:Prophylactic; influenza; respiratory syncytial virus; alveolar macrophage; interferon

摘要:"Infection caused by respiratory viruses can lead to a severe respiratory disease and even death. Vaccination is the most effective way to prevent the disease, but it cannot be quickly applied when facing an emerging infectious disease. Here, we demonstrated that immunization with an aluminium-zinc hybrid particulate adjuvant (FH-001) alone, bearing great resemblance in morphology with commonly used aluminium-based adjuvants in vaccines, could quickly induce mice to generate a broadly protective immune response to resist the lethal challenge of influenza B viruses. Furthermore, a multi-omics-based analysis revealed that the alveolar macrophage and type I interferon pathway, rather than adaptive immunity and type II interferon pathway, were essential for the observed prophylactic effect of FH-001. More importantly, a similar protective effect was observed against influenza A virus strain A/Shanghai/02/2013(H7N9), A/California/04/2009(H1N1) and respiratory syncytial virus. Therefore, we introduced here a new and promising strategy that can be quickly applied during the outbreak of emerging respiratory viruses."

基金机构:"National Natural Science Foundation of China [32070925, 82041038]; National Key Research and Development Programs of China [2020YFC0842600]; Guangdong Provincial Department of Science and Technology [2020B1111340033]"

基金资助正文:"This work was supported by grants from the National Natural Science Foundation of China (Grant nos. 32070925 and 82041038), National Key Research and Development Programs of China (Grant No. 2020YFC0842600), Guangdong Provincial Department of Science and Technology (2020B1111340033)."