Association between vitamin D supplementation and cancer incidence and mortality: A trial sequential meta-analysis of randomized controlled trials

作者全名："Guo, Zhangyou; Huang, Ming; Fan, Dandan; Hong, Yuan; Zhao, Min; Ding, Rong; Cheng, Yao; Duan, Shigang"

作者地址："[Guo, Zhangyou; Huang, Ming; Fan, Dandan; Ding, Rong] Kunming Med Univ, Yunnan Canc Hosp, Yunnan Canc Ctr, Affiliated Hosp 3, Kunming, Yunnan, Peoples R China; [Hong, Yuan] Kunming Med Univ, Inst Expt Diagnost Yunnan Prov, Key Lab Lab Med Yunnan Prov, Med Lab,Affiliated Hosp 1, Kunming, Yunnan, Peoples R China; [Zhao, Min] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders Chongqin, Dept Neonatol, Minist Educ,Key Lab Child Dev & Disorders,Childre, Chongqing, Peoples R China; [Zhao, Min] Chongqing Engn Res Ctr Stem Cell Therapy, Chongqing Key Lab Pediat, Chongqing Key Lab Child Hlth & Nutr, Int Sci & Technol Cooperat Base Child Dev & Crit, Chongqing, Peoples R China; [Cheng, Yao] Chongqing Med Univ, Affiliated Hosp 2, Dept Hepatobiliary Surg, Chongqing, Peoples R China; [Duan, Shigang] Guangdong Med Univ, Dept Hepatobiliary Surg, Affiliated Hosp 2, Zhanjiang, Peoples R China"

通信作者："Duan, SG (通讯作者)，Guangdong Med Univ, Dept Hepatobiliary Surg, Affiliated Hosp 2, Zhanjiang, Peoples R China."

来源：CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

ESI学科分类：AGRICULTURAL SCIENCES

WOS号：WOS:000776123500001

JCR分区：Q1

影响因子：10.2

年份：2022

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Review; Early Access

关键词：Vitamin D; cancer; incidence; mortality; trial sequential analysis; meta-analysis

摘要："Observational studies and clinical trials have evaluated the associations between vitamin D supplementation and cancer incidence/mortality and obtained mixed results. Previous meta-analyses have also yielded inconsistent conclusions. In this paper, we conduct an updated meta-analysis by including current randomized clinical trials (RCTs) to assess the association between vitamin D supplementation and cancer incidence and mortality. The PubMed, Scopus and Embase databases were systematically searched from their inception to 6 February 2022. Fixed-effects meta-analyses were conducted. Trial sequential analyses were performed using a risk ratio reduction threshold of 10% for cancer incidence and mortality. Twenty-six RCTs were eligible, and pooled results indicated that vitamin D supplementation, compared to placebo with/without calcium, was not associated with a reduction in total cancer incidence (risk ratio: 0.98, 95% CI: 0.94, 1.02; I-2 = 0%). In contrast, vitamin D supplementation significantly reduced total cancer mortality (risk ratio: 0.88, 95% CI: 0.8, 0.96; I-2 = 0%). Moreover, trial sequential analysis provided reliable evidence that supplementation with vitamin D lowered the relative risk of total cancer mortality by 10%. Our updated meta-analysis suggested that vitamin D supplementation did not reduce total cancer incidence but significantly lowered total cancer mortality. Supplemental data for this article is available online at https://doi.org/10.1080/10408398.2022.2056574 ."

基金机构："National Natural Science Foundation of China [81701950, 82172135]; Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University [KY2019Y002]"

基金资助正文：This work was supported by the National Natural Science Foundation of China (Grant numbers 81701950 and 82172135) and the Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University (Grant No. KY2019Y002).