Impacts of eosinophil percentage on prognosis acute type A aortic dissection patients

作者全名："Shao, Yue; Ye, Liu; Shi, Hao-ming; Wang, Xin-mei; Luo, Jun; Liu, Lu; Wu, Qing-chen"

作者地址："[Shao, Yue; Shi, Hao-ming; Luo, Jun; Liu, Lu; Wu, Qing-chen] Chongqing Med Univ, Affiliated Hosp 1, Dept Cardiothorac Surg, 1 Youyi Rd, Chongqing, Peoples R China; [Ye, Liu] Chongqing Med Univ, Affiliated Hosp 1, Branch 1, Chongqing, Peoples R China; [Wang, Xin-mei] Chongqing Med Univ, Dept Pathol, Chongqing, Peoples R China"

通信作者："Wu, QC (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Cardiothorac Surg, 1 Youyi Rd, Chongqing, Peoples R China."

来源：BMC CARDIOVASCULAR DISORDERS

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000777398100004

JCR分区：Q3

影响因子：2.1

年份：2022

卷号：22

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Eosinophil; Acute type A aortic dissection; Mortality; Inflammatory cells; Thrombus; Medical Information Mart for Intensive Care

摘要："Background Eosinophils are pro-inflammatory cells involved in thrombosis and have been proposed as a prognosis marker in acute ischemic stroke and ST-elevation myocardial Infarction. Here, we sought to clarify the prognostic value of eosinophil percentage (EOS%) in patients with acute type A aortic dissection (AAAD). Methods We examined 183 consecutive AAAD patients. Based on the optimum cut-off value of EOS% determined by X-tile software, patients were classified into the low EOS% (EOS% <= 0.1) and high EOS% groups (EOS% > 0.1). We performed multivariate regression analysis and Kaplan-Meier (KM) survival curves to assess the association between EOS% and mortality. Eosinophil accumulation in aortic dissection intraluminal thrombus was confirmed using hematoxylin-eosin (H&E) staining. An external cohort from Medical Information Mart for Intensive Care IV was performed to validate the results. Results Relative to surviving patients, those who died during hospitalization had significantly lower EOS% (p = 0.001) but significantly higher WBC (p = 0.002) and neutrophil (p = 0.001) counts. Multivariate regression analysis identified EOS% as an independent predictor of in-hospital and 1-year mortality. KM curves revealed that 1-year cumulative mortality was significantly higher in the low EOS% group, although it was mainly attributed to the higher 30-day mortality. H&E staining revealed massive infiltration of eosinophils in all 20 thrombus specimens. The external validation confirmed that relative to survivors, patients with in-hospital mortality (p = 0.010) had significantly lower EOS%. Moreover, multivariate regression analyses identified that decreased EOS% was independently significantly associated with in-hospital mortality. Conclusions Low EOS% is significantly related to increased mortality rates in AAAD patients."

基金机构：Health Bureau of Chongqing [2021MSXM005]

基金资助正文：LThis project was supported by a grant from the Health Bureau of Chongqing (2021MSXM005).