Methodology and experiences of rapid advice guideline development for children with COVID-19: responding to the COVID-19 outbreak quickly and efficiently

作者全名："Zhou, Qi; Li, Qinyuan; Estill, Janne; Wang, Qi; Wang, Zijun; Shi, Qianling; Zhang, Jingyi; Zhang, Xiaobo; Mathew, Joseph L.; Smyth, Rosalind L.; Nurdiati, Detty; Fu, Zhou; Xu, Hongmei; Zheng, Xianlan; Zhao, Xiaodong; Lu, Quan; Liu, Hui; Xun, Yangqin; Li, Weiguo; Yang, Shu; Feng, Xixi; Wang, Mengshu; Lei, Junqiang; Luo, Xiaoping; Wu, Liqun; Lu, Xiaoxia; Lee, Myeong Soo; Zhao, Shunying; Chan, Edwin Shih-Yen; Qian, Yuan; Tu, Wenwei; Dong, Xiaoyan; Li, Guobao; Zhao, Ruiqiu; He, Zhihui; Zhao, Siya; Liu, Xiao; Li, Qiu; Yang, Kehu; Luo, Zhengxiu; Liu, Enmei; Chen, Yaolong"

作者地址："[Zhou, Qi; Wang, Zijun; Xun, Yangqin; Yang, Kehu; Chen, Yaolong] Lanzhou Univ, Evidence Based Med Ctr, Sch Basic Med Sci, Lanzhou 730000, Peoples R China; [Zhou, Qi] Lanzhou Univ, Inst Hlth Data Sci, Lanzhou, Peoples R China; [Li, Qinyuan; Fu, Zhou; Li, Weiguo; Luo, Zhengxiu; Liu, Enmei] Chongqing Med Univ, Childrens Hosp,Chongqing Key Lab Pediat, Dept Resp Med,Minist Educ,Key Lab Child Dev & Dis, Natl Clin Res Ctr Child Hlth & Disorders, Chongqing, Peoples R China; [Estill, Janne] Univ Geneva, Inst Global Hlth, Geneva, Switzerland; [Estill, Janne] Univ Bern, Inst Math Stat & Actuarial Sci, Bern, Switzerland; [Wang, Qi] McMaster Univ, Fac Hlth Sci, Dept Hlth Res Methods Evidence & Impact, Hamilton, ON, Canada; [Wang, Qi] McMaster Univ, McMaster Hlth Forum, Hamilton, ON, Canada; [Shi, Qianling] Lanzhou Univ, Sch Clin Med 1, Lanzhou, Peoples R China; [Zhang, Jingyi; Liu, Hui; Zhao, Siya; Liu, Xiao] Lanzhou Univ, Sch Publ Hlth, Lanzhou, Peoples R China; [Zhang, Xiaobo] Fudan Univ, Natl Childrens Med Ctr, Childrens Hosp, Shanghai, Peoples R China; [Mathew, Joseph L.] PGIMER Chandigarh, Adv Pediat Ctr, Chandigarh, India; [Smyth, Rosalind L.] UCL Great Ormond St Inst Child Hlth, London, England; [Nurdiati, Detty] Univ Gadjah Mada, Fac Med Publ Hlth & Nursing, Cochrane Indonesia, Yogyakarta, Indonesia; [Xu, Hongmei; Zhao, Ruiqiu] Chongqing Med Univ, Rtment Infect Dis,Childrens Hosp, Natl Clin Res Ctr Child Hlth & Disorders, Minist Educ,Key Lab Child Dev & Disorders,Chongqi, Chongqing, Peoples R China; [Zheng, Xianlan] Chongqing Med Univ, Childrens Hosp,Dept Nursing,Chongqing Key Lab Ped, Natl Clin Res Ctr Child Hlth & Disorders, Minist Educ,Key Lab Child Dev & Disorders, Chongqing, Peoples R China; [Zhao, Xiaodong] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Dept Pediat Res Inst,Childrens Hosp,China Int Sci, Minist Educ,Key Lab Child Dev & Disorders, Chongqing, Peoples R China; [Lu, Quan] Shanghai Jiao Tong Univ, Shanghai Childrens Hosp, Shanghai, Peoples R China; [Yang, Shu] Chengdu Univ Tradit Chinese Med, Digital Inst Med, Chengdu, Peoples R China; [Feng, Xixi] Chengdu Med Coll, Dept Publ Hlth, Chengdu, Peoples R China; [Wang, Mengshu; Lei, Junqiang] Lanzhou Univ, Dept Radiol, Hosp 1, Lanzhou, Peoples R China; [Luo, Xiaoping] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Pediat, Wuhan, Peoples R China; [Wu, Liqun] Shenzhen Hlth Dev Res Ctr, Shenzhen, Peoples R China; [Lu, Xiaoxia] Huazhong Univ Sci & Technol, Wuhan Childrens Hosp, Tongji Med Coll, Dept Resp Med, Wuhan, Peoples R China; [Lee, Myeong Soo] Korea Inst Oriental Med, Clin Med Div, Daejeon, South Korea; [Lee, Myeong Soo] Univ Sci & Technol, Korean Convergence Med, Daejeon, South Korea; [Lee, Myeong Soo] Tianjin Univ Tradit Chinese Med, Tianjin, Peoples R China; [Zhao, Shunying] Beijing Childrens Hosp, Beijing, Peoples R China; [Chan, Edwin Shih-Yen] Duke Natl Univ Singapore, Ctr Quantitat Med, Off Clin Sci, Med Sch, Singapore, Singapore; [Chan, Edwin Shih-Yen] Singapore Clin Res Inst, Singapore, Singapore; [Qian, Yuan] Capital Inst Pediat, Beijing Key Lab Etiol Viral Dis Children, Beijing, Peoples R China; [Tu, Wenwei] Univ Hong Kong, Li Ka Shing Fac Med, Dept Pediat & Adolescent Med, Hong Kong, Peoples R China; [Dong, Xiaoyan] Shanghai Childrens Hosp, Shanghai, Peoples R China; [Li, Guobao] Natl Clin Res Ctr Infect Dis, Shenzhen, Peoples R China; [Li, Guobao] Shenzhen Third Peoples Hosp, Shenzhen, Peoples R China; [He, Zhihui] Chongqing Ninth Peoples Hosp, Chongqing, Peoples R China; [Li, Qiu] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Minist Educ,Key Lab Child Dev & Disorders, Chongqing Key Lab Pediat,Dept Nephrol,Childrens H, Chongqing, Peoples R China; [Yang, Kehu] Key Lab Evidence Based Med & Knowledge Translat G, Lanzhou, Peoples R China; [Yang, Kehu; Chen, Yaolong] WHO Collaborating Ctr Guideline Implementat & Kno, Lanzhou, Peoples R China; [Chen, Yaolong] GIN Asia, Lanzhou 730000, Peoples R China; [Chen, Yaolong] Lanzhou GRADE Ctr, Lanzhou 730000, Peoples R China; [Chen, Yaolong] Lanzhou Univ, Sch Basic Med Sci, Chinese Acad Med Sci 2021RU017, Res Unit Evidence Based Evaluat & Guidelines, Lanzhou 730000, Peoples R China"

通信作者："Chen, YL (通讯作者)，Lanzhou Univ, Evidence Based Med Ctr, Sch Basic Med Sci, Lanzhou 730000, Peoples R China.; Luo, ZX; Liu, EM (通讯作者)，Chongqing Med Univ, Childrens Hosp,Chongqing Key Lab Pediat, Dept Resp Med,Minist Educ,Key Lab Child Dev & Dis, Natl Clin Res Ctr Child Hlth & Disorders, Chongqing, Peoples R China.; Chen, YL (通讯作者)，WHO Collaborating Ctr Guideline Implementat & Kno, Lanzhou, Peoples R China.; Chen, YL (通讯作者)，GIN Asia, Lanzhou 730000, Peoples R China.; Chen, YL (通讯作者)，Lanzhou GRADE Ctr, Lanzhou 730000, Peoples R China.; Chen, YL (通讯作者)，Lanzhou Univ, Sch Basic Med Sci, Chinese Acad Med Sci 2021RU017, Res Unit Evidence Based Evaluat & Guidelines, Lanzhou 730000, Peoples R China."

来源：BMC MEDICAL RESEARCH METHODOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000777633900003

JCR分区：Q1

影响因子：4

年份：2022

卷号：22

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Methodology; Rapid Advice Guidelines; COVID-19; Indirect evidence

摘要："Background Rapid Advice Guidelines (RAG) provide decision makers with guidance to respond to public health emergencies by developing evidence-based recommendations in a short period of time with a scientific and standardized approach. However, the experience from the development process of a RAG has so far not been systematically summarized. Therefore, our working group will take the experience of the development of the RAG for children with COVID-19 as an example to systematically explore the methodology, advantages, and challenges in the development of the RAG. We shall propose suggestions and reflections for future research, in order to provide a more detailed reference for future development of RAGs. Result The development of the RAG by a group of 67 researchers from 11 countries took 50 days from the official commencement of the work (January 28, 2020) to submission (March 17, 2020). A total of 21 meetings were held with a total duration of 48 h (average 2.3 h per meeting) and an average of 16.5 participants attending. Only two of the ten recommendations were fully supported by direct evidence for COVID-19, three recommendations were supported by indirect evidence only, and the proportion of COVID-19 studies among the body of evidence in the remaining five recommendations ranged between 10 and 83%. Six of the ten recommendations used COVID-19 preprints as evidence support, and up to 50% of the studies with direct evidence on COVID-19 were preprints. Conclusions In order to respond to public health emergencies, the development of RAG also requires a clear and transparent formulation process, usually using a large amount of indirect and non-peer-reviewed evidence to support the formation of recommendations. Strict following of the WHO RAG handbook does not only enhance the transparency and clarity of the guideline, but also can speed up the guideline development process, thereby saving time and labor costs."

基金机构："National Clinical Research Center for Child Health and Disorders (Children's Hospital of Chongqing Medical University, Chongqing, China) [NCRCCHD-2020-EP-01]; Special Fund for Key Research and Development Projects in Gansu Province in 2020; fourth batch of ""Special Project of Science and Technology for Emergency Response to COVID-19"" of Chongqing Science and Technology Bureau; Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province [GSEBMKT-2020YJ01]; Fundamental Research Funds for the Central Universities [lzujbky-2020-sp14]"

基金资助正文："This work was supported by grants from National Clinical Research Center for Child Health and Disorders (Children's Hospital of Chongqing Medical University, Chongqing, China) (grant number NCRCCHD-2020-EP-01); Special Fund for Key Research and Development Projects in Gansu Province in 2020; The fourth batch of ""Special Project of Science and Technology for Emergency Response to COVID-19"" of Chongqing Science and Technology Bureau; Special funding for prevention and control of emergency of COVID-19 from Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province (grant number No. GSEBMKT-2020YJ01); The Fundamental Research Funds for the Central Universities (lzujbky-2020-sp14)."