Plasma C1q/tumor necrosis factor-related protein-3 concentrations are associated with diabetic peripheral neuropathy

作者全名："Lin, Ke; Yang, Liu; Xiong, Yuyuan; Feng, Keduo; Zeng, Wang; Deng, Bo"

作者地址："[Lin, Ke; Yang, Liu; Feng, Keduo; Zeng, Wang] Chongqing Univ, Chongqing Univ Cent Hosp, Chongqing Emergency Med Ctr, Dept Neurol, Chongqing, Peoples R China; [Xiong, Yuyuan] Chongqing Med Univ, Dept Prosthodont, Stomatobl Hosp, Chongqing, Peoples R China; [Deng, Bo] Chongqing Univ, Chongqing Univ Cent Hosp, Chongqing Emergency Med Ctr, Dept Endocrinol,Coll Med,Coll Bioengn, Chongqing, Peoples R China"

通信作者："Lin, K (通讯作者)，Chongqing Univ, Chongqing Univ Cent Hosp, Chongqing Emergency Med Ctr, Dept Neurol, Chongqing, Peoples R China.; Deng, B (通讯作者)，Chongqing Univ, Chongqing Univ Cent Hosp, Chongqing Emergency Med Ctr, Dept Endocrinol,Coll Med,Coll Bioengn, Chongqing, Peoples R China."

来源：BMJ OPEN DIABETES RESEARCH & CARE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000779000100003

JCR分区：Q2

影响因子：4.1

年份：2022

卷号：10

期号：2

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："Introduction To analyze the associations of circulating C1g/tumor necrosis factor-related protein-3 (CTRP3) concentrations with several metabolic parameters and to investigate the possible role of CTRP3 in subjects with diabetic peripheral neuropathy (DPN). Research design and methods A total of 347 participants were recruited in this study, and plasma CTRP3 concentrations were analyzed in subjects with DPN (n=172) and without DPN (non-DPN, n=175). The nerve conduction test and oral glucose tolerance test were performed, and Neuropathy Symptom Score (NSS)/Neuropathy Disability Score (NDS) and biochemical parameters were measured in all participants. Results Plasma CTRP3 concentrations were significantly lower in patients with DPN compared with those in patients with diabetes without DPN (p<0.01), despite the comparable glucose and lipid metabolism levels in both groups. Groups with a higher plasma CTRP3 level had a faster nerve conduction velocity. In addition, plasma CTRP3 concentrations were negatively correlated with hemoglobin A1c (HbA1c), urea acid (UA), triglyceride, NSS and NDS (p<0.05) after being adjusted for age and sex. Multivariate logistic regression analysis revealed that plasma CTRP3 concentrations were significantly correlated with DPN after being controlled for age, sex, body mass index, HbA1c, blood pressure, lipid profiles, and renal function. Conclusions Plasma CTRP3 concentrations were significantly lower in patients with DPM and positively correlated with nerve conduction velocity. The relationship between CTRP3 levels and DPN is independent of the glucose and lipid status. Therefore, circulating CTRP3 might serve as a predictor of impairment of nerve conduction in patients with DPN."

基金机构："basic research and frontier exploration project of Yuzhong District, Chongqing [20200143]"

基金资助正文："This work was supported by grants from basic research and frontier exploration project of Yuzhong District, Chongqing (No. 20200143)."