MOXD1 knockdown suppresses the proliferation and tumor growth of glioblastoma cells via ER stress-inducing apoptosis

作者全名："Shi, Pengfei; Xu, Jie; Xia, Fanwei; Wang, Yinggang; Ren, Jie; Liang, Ping; Cui, Hongjuan"

作者地址："[Shi, Pengfei; Xu, Jie; Xia, Fanwei; Cui, Hongjuan] Southwest Univ, State Key Lab Silkworm Genome Biol, Chongqing 400716, Peoples R China; [Wang, Yinggang; Ren, Jie; Cui, Hongjuan] Southwest Univ, Canc Ctr, Med Res Inst, Chongqing 400716, Peoples R China; [Liang, Ping] Chongqing Med Univ, Natl Clin Res Ctr Child & Disorders, Dept Neurosurg,Childrens Hosp, Minist Educ Key Lab Child Dev & Disorders, Chongqing 400014, Peoples R China; [Liang, Ping] Chongqing Key Lab Pediat, Chongqing 400014, Peoples R China"

通信作者："Cui, HJ (通讯作者)，Southwest Univ, State Key Lab Silkworm Genome Biol, Chongqing 400716, Peoples R China.; Cui, HJ (通讯作者)，Southwest Univ, Canc Ctr, Med Res Inst, Chongqing 400716, Peoples R China.; Liang, P (通讯作者)，Chongqing Med Univ, Natl Clin Res Ctr Child & Disorders, Dept Neurosurg,Childrens Hosp, Minist Educ Key Lab Child Dev & Disorders, Chongqing 400014, Peoples R China.; Liang, P (通讯作者)，Chongqing Key Lab Pediat, Chongqing 400014, Peoples R China."

来源：CELL DEATH DISCOVERY

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:000779755500004

JCR分区：Q2

影响因子：7

年份：2022

卷号：8

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："Oxygenase-catalyzed reduction and activation of oxygen molecules and the incorporation of oxygen atoms into organic molecules are undoubtedly necessary in the process of tumor development, and it is also one of the research hotspots in recent years. MOXD1 belongs to the copper-dependent monooxygenase family. The expression of MOXD1 is one of the characteristics of early tumor development. However, it is not understandable that the biological function and molecular mechanism of MOXD1 in Glioblastoma (GBM). In this study, high MOXD1 expression is strongly associated with poor survival of the patient with GBM. Moreover. MOXD1 knockdown can inhibit cell viability, proliferation, migration, invasion, and tumorigenesis of GBM cells. This is also proven for the first time that MOXD1 can bind to beta 3GnT2 and affect the glycosylation modification of some proteins. In addition, knockdown of MOXD1 induces endoplasmic reticulum (ER) stress and triggers the ER-mitochondrial apoptosis pathway. Taken together, these results reveal that MOXD1 is involved in the occurrence and development of GBM, and also provide a new strategy for targeted therapy."

基金机构：Natural Science Foundation of Chongqing [cstc2019jcyjzdxmX0033]; Graduate Research and Innovation Project of Chongqing of China [2019CYB19117]

基金资助正文："This research was supported by the Natural Science Foundation of Chongqing (cstc2019jcyjzdxmX0033), the Graduate Research and Innovation Project of Chongqing of China (No. 2019CYB19117)."