Lymphadenectomy in Primary Fallopian Tube Cancer is Associated with Improved Survival

作者全名："Xiao, Yao; Liu, Yue-Xi; Li, Ruo-Nan; Wei, Xing; Wang, Qing-Miao; Gu, Qiu-Ying; Hua Linghu"

作者地址："[Xiao, Yao; Liu, Yue-Xi; Li, Ruo-Nan; Wei, Xing; Wang, Qing-Miao; Gu, Qiu-Ying; Hua Linghu] Chongqing Med Univ, Dept Gynecol, Affiliated Hosp 1, Chongqing 400016, Peoples R China"

通信作者："Hua, LH (通讯作者)，Chongqing Med Univ, Dept Gynecol, Affiliated Hosp 1, Chongqing 400016, Peoples R China."

来源：JOURNAL OF INVESTIGATIVE SURGERY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000780934800001

JCR分区：Q2

影响因子：1.9

年份：2022

卷号：35

期号：6

开始页：1417

结束页：1423

文献类型：Article

关键词：Gynecology; lymphadenectomy; fallopian tube cancer; surgery; prognosis

摘要："Background and Objectives: Primary fallopian tube cancer (PFTC) shares the same diagnostic and management guidelines with epithelial ovarian cancer (EOC). The LION trail raised concerns regarding the role of systematic pelvic and para-aortic lymphadenectomy during debulking surgery. We aimed to evaluate the significance of lymphadenectomy in PFTC survival. Methods: This retrospective study analyzed the clinical features and survival of patients with PFTC who underwent primary surgery in our center between January 2013 and October 2020. Results: Sixty-one patients diagnosed with PFTC were included in the study. Twenty-five (41.0%, 25/61) were diagnosed with FIGO (International Federation of Gynecology and Obstetrics) stages I/II and 36 (59.0%, 36/61) were diagnosed with stage III/IV. Twenty-nine (47.5%, 29/61) underwent pelvic lymphadenectomy with or without para-aortic lymphadenectomy, among which 12 (41.4%, 12/29) had lymph node metastasis confirmed by postoperative pathology. The mean progression-free survival was 60.4 months in the lymphadenectomy group and 37.8 months in the no-lymphadenectomy group (p=0.042, HR 0.374, 95% CI 0.145-0.966). Conclusions: PFTC is often diagnosed earlier and has a better prognosis than EOC. Most patients with PFTC would benefit from lymphadenectomy. However, the extent to which this association translates to a more diverse population needs to be further identified."

基金机构：　

基金资助正文：