Honokiol improves endothelial function in type 2 diabetic rats via alleviating oxidative stress and insulin resistance

作者全名："He, An; Yu, Huilin; Hu, Yu; Chen, Huiling; Li, Xiang; Shen, Jian; Zhuang, Rongjuan; Chen, Yi; Sasmita, Bryan Richard; Luo, Minghao; Lv, Dingyi"

作者地址："[He, An; Yu, Huilin; Hu, Yu; Chen, Huiling; Li, Xiang; Shen, Jian; Sasmita, Bryan Richard; Luo, Minghao; Lv, Dingyi] Chongqing Med Univ, Affiliated Hosp 1, Dept Cardiol, Chongqing 400016, Peoples R China; [Zhuang, Rongjuan; Chen, Yi] Chongqing Med Univ, Affiliated Hosp 1, Dept Pulm & Crit Care Med, Chongqing 400016, Peoples R China"

通信作者："Luo, MH; Lv, DY (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Cardiol, Chongqing 400016, Peoples R China."

来源：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:000781500300001

JCR分区：Q2

影响因子：3.1

年份：2022

卷号：600

期号：　

开始页：109

结束页：116

文献类型：Article

关键词：Honokiol; Diabetes; Endothelial dysfunction; Insulin resistance; Oxidative stress

摘要："We aimed to examine the effect of Honokiol (HKL) on endothelial dysfunction in type 2 diabetic rats and its possible mechanism. A high-fat diet and streptozotocin (STZ) were used to establish the type 2 diabetic model in rats. Part of these rats were intraperitoneally injected with HKL 10 mg/kg daily. Then the expression of Ser1177 phosphorylation of endothelial nitric oxide synthase (p-eNOS), eNOS, and CD31, vasodilation function, insulin signaling, indicators of oxidative stress and relative signaling pathway were measured. Human umbilical vein endothelial cells (HUVECs) were used to explore the underlying mechanism of the effect of HKL on high glucose-related endothelial injury in vitro. The data showed that HKL could reverse the decline of the expression of p-eNOS and CD31, endothelium-related vasodilation dysfunction, insulin resistance and activation of oxidative stress induced by type 2 diabetes in vivo. The similar results were obtained in vitro. In summary, our study demonstrates that HKL improves endothelial function and diminishes insulin resistance and oxidative stress, suggesting that HKL could be used as a treatment option for diabetes in the future. (c) 2022 Elsevier Inc. All rights reserved."

基金机构：　

基金资助正文：