Clinical Characteristics of Children With Anti-N-Methyl-D-Aspartate Receptor Encephalitis After Japanese Encephalitis

作者全名："Luo, Hanyu; Ding, Xiao; Li, Yuhang; Ma, Jiannan; Liu, Benke; Zhou, Lvli; Zheng, Yaxin; Jiang, Yan; Li, Xiujuan; Jiang, Li"

作者地址："[Luo, Hanyu; Ding, Xiao; Li, Yuhang; Ma, Jiannan; Liu, Benke; Zhou, Lvli; Zheng, Yaxin; Jiang, Yan; Li, Xiujuan; Jiang, Li] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Minist Educ Key Lab Child Dev & Disorders, Dept Neurol,Childrens Hosp, Chongqing, Peoples R China; [Ding, Xiao] Qingdao Univ, Qingdao Women & Childrens Hosp, Qingdao, Peoples R China; [Liu, Benke] Shenzhen Baoan Womens & Childrens Hosp, Shenzhen, Peoples R China"

通信作者："Jiang, L (通讯作者)，136 Zhongshan 2nd Rd, Chongqing 400014, Peoples R China."

来源：PEDIATRIC NEUROLOGY

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:000781661900007

JCR分区：Q1

影响因子：3.8

年份：2022

卷号：130

期号：　

开始页：46

结束页：52

文献类型：Article

关键词：Anti; N -methyl; D -aspartate receptor; encephalitis; Anti-NMDAR encephalitis; Japanese encephalitis; Children; Characteristics

摘要："Background: Viral encephalitis is an important trigger for anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis. We analyzed the clinical characteristics of anti-NMDAR encephalitis after Japanese encephalitis (JE) in children.Methods: Clinical data of 185 children with anti-NMDAR encephalitis were retrospectively reviewed. Patients with a history of viral encephalitis other than JE or who were identified with other autoantibodies were excluded.Results: Twenty children with anti-NMDAR encephalitis after JE were enrolled with a median age of 6 years and 10 months (interquartile range [IQR]: 3 years to 11 years and 5 months). The median time from JE to anti-NMDAR encephalitis was 29 (IQR: 25 to 32) days. At 12 months, most patients (17 of 18) recovered to at least their baseline modified Rankin scale (mRS) scores caused by JE. One hundred forty two children with classical anti-NMDAR encephalitis were enrolled. Compared with classical antiNMDAR encephalitis, patients after JE had significantly more decreased level of consciousness (50% vs 18.3%, P = 0.003), more autonomic dysfunction (30.0% vs 9.9%, P = 0.021), fewer psychiatric or behavioral symptoms (70.0% vs 90.8%, P = 0.016), fewer seizures (25.0% vs 68.3%, P < 0.001), lesser improvement 4 weeks after immunotherapy (35.0% vs 73.2%, P = 0.001), and worse outcomes at 12 months (median mRS: 1 vs 0, P < 0.001).Conclusions: Anti-NMDAR encephalitis after JE in children mainly occurred within two months. Their clinical manifestation may differ from classical anti-NMDAR encephalitis. The prognosis of children with anti-NMDAR encephalitis after JE probably depends on the neurological sequelae after JE.(c) 2022 Elsevier Inc. All rights reserved."

基金机构：Chongqing Postgraduate Research and Innovation Project [CYB21184]

基金资助正文：Funding: This work was supported by the Chongqing Postgraduate Research and Innovation Project (grant No: CYB21184) .