The biological function of metazoan-specific subunit nuclear factor related to kappaB binding protein of INO80 complex

作者全名："Peng, Qiyao; Wan, Dan; Zhou, Rongrong; Luo, Hongyu; Wang, Junyi; Ren, Lingyan; Zeng, Yajun; Yu, Chao; Zhang, Shuihan; Huang, Xuekuan; Peng, Yongbo"

作者地址："[Peng, Qiyao; Wang, Junyi; Zeng, Yajun; Yu, Chao; Peng, Yongbo] Chongqing Med Univ, Coll Pharm, Chongqing Key Lab Pharmaceut Metab Res, Chongqing 400016, Peoples R China; [Peng, Qiyao; Wan, Dan; Zhou, Rongrong; Zhang, Shuihan; Peng, Yongbo] Hunan Acad Tradit Chinese Med, Inst Chinese Med, Changsha 410208, Peoples R China; [Peng, Qiyao; Wan, Dan; Zhou, Rongrong; Zhang, Shuihan; Peng, Yongbo] Hunan Univ Chinese Med, Changsha 410208, Peoples R China; [Luo, Hongyu; Huang, Xuekuan] Chongqing Med Univ, Coll Tradit Chinese Med, Chongqing Key Lab Tradit Chinese Med Prevent & Cu, Chongqing 410016, Peoples R China; [Ren, Lingyan] Chongqing Univ Sci & Technol, Sch Safety Engn, Chongqing 401331, Peoples R China; [Zeng, Yajun] Chongqing Med Univ, Childrens Hosp, Dept Pharm, Chongqing 400014, Peoples R China"

通信作者："Peng, YB (通讯作者)，Chongqing Med Univ, Coll Pharm, Chongqing Key Lab Pharmaceut Metab Res, Chongqing 400016, Peoples R China.; Huang, XK (通讯作者)，Chongqing Med Univ, Coll Tradit Chinese Med, Chongqing Key Lab Tradit Chinese Med Prevent & Cu, Chongqing 410016, Peoples R China."

来源：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:000781820900002

JCR分区：Q1

影响因子：8.2

年份：2022

卷号：203

期号：　

开始页：176

结束页：183

文献类型：Review

关键词：NFRKB; INO80; Function and structure

摘要："The INO80 chromatin remodeling complex plays an essential role in the regulation of gene transcription, which participate in a variety of important biological processes in cells including DNA repair and DNA replication. Difference from the yeast INO80 complex, metazoan INO80 complex have the specific subunit G, which is known as nuclear factor related to kappaB binding protein (NFRKB). Recently, NFRKB has been received much attention in many aspects, such as DNA repair, cell pluripotency, telomere protection, and protein activity regulation. To dig the new function of metazoan INO80 complex, a better understanding of the role of NFRKB is required. In this review, we provide an overview of the structure and function of NFRKB and discuss its potential role in cancer treatment and telomere regulation. Overall, this review provides an important reference for further research of the INO80 complex and NFRKB."

基金机构：National Natural Science Foundation of China [81202896]; Key Research and Development Project of Hunan Province [2019NK2101]; Discipline Talents Program of School of Pharmacy and Innovate Start-up Project in Chongqing Medical Univer-sity [YXY2021XSZ04]; Hong Kong Scholars Program [XJ2017054]

基金资助正文："Acknowledgements This work is supported by the National Natural Science Foundation of China (81202896) , Key Research and Development Project of Hunan Province (2019NK2101) , Discipline Talents Program of School of Pharmacy and Innovate Start-up Project in Chongqing Medical Univer-sity (YXY2021XSZ04) , and Hong Kong Scholars Program (XJ2017054) ."