Postoperative survival of extrahepatic and intrahepatic cholangiocarcinoma after surgery: a population-based cohort

作者全名："Liu, Wei-Wen; Tu, Jian-Fei; Ying, Xi-Hui; Chen, Zheng-Ju; Wang, Yun-Bing"

作者地址："[Liu, Wei-Wen; Tu, Jian-Fei; Ying, Xi-Hui] Wenzhou Med Univ, Dept Radiol, Affiliated Hosp 5, Lishui, Zhejiang, Peoples R China; [Chen, Zheng-Ju] Sichuan Univ, Lab Pathol, West China Hosp, Chengdu, Sichuan, Peoples R China; [Wang, Yun-Bing] Chongqing Med Univ, Dept Hepatobiliary Surg, Affiliated Hosp 2, Chongqing, Peoples R China"

通信作者："Wang, YB (通讯作者)，Chongqing Med Univ, Dept Hepatobiliary Surg, Affiliated Hosp 2, Chongqing, Peoples R China."

来源：BMJ OPEN

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000783232500013

JCR分区：Q1

影响因子：2.9

年份：2022

卷号：12

期号：4

开始页：　

结束页：　

文献类型：Article

关键词：hepatobiliary tumours; gastroenterology; gastrointestinal tumours; hepatobiliary disease

摘要："Objectives The study was designed to clarify the difference between extrahepatic cholangiocarcinoma (ECC) and intrahepatic cholangiocarcinoma (ICC) in postoperative cancer-specific death. Design Patients diagnosed with ECC and ICC after surgery, who are identified from the Surveillance, Epidemiology and End Results programme, are eligible for this retrospective cohort study. Setting Survival between groups was compared using the traditional Kaplan-Meier method and the cumulative incidence function (CIF) method. Propensity score-matched (PSM) analysis was conducted to balance the differences in vital variables between groups. The HR and 95% CI for ECC relative to ICC were used to quantify the risk of death. Subgroup analysis was further used to evaluate the stability of the differences between groups. Results The study included 876 patients with ECC and 1194 patients with ICC. Before PSM, with the Kaplan-Meier method, postoperative overall survival and cancer-specific death for ECC were worse than those for ICC. However, with the CIF method, no difference in postoperative cancer-specific death was found. After PSM, all differences in the considered traits were balanced, and 173 pairs of patients were retained. Survival analysis found that there was no difference in postoperative all-cause death (Kaplan-Meier method, p=0.186) or cancer-specific death (Kaplan-Meier and CIF methods, p=0.500 and p=0.913, respectively), which was consistent with subgroup analysis. Conclusions ECC and ICC showed no difference in postoperative cancer-specific death, both in the natural state and in multiple variable-matched conditions."

基金机构：Chongqing medical scientific research project (Joint project of Chongqing Health Commission and Science and Technology Bureau) [2021MSXM139]; Programme for Science and Technology Department of Zhejiang Province [LGF18H220001]; Zhejiang Province Health Department [2018253605]; Science and Technology Department of Lishui City [2017ZDXK05]

基金资助正文："y The study was funded by Chongqing medical scientific research project (Joint project of Chongqing Health Commission and Science and Technology Bureau: No. 2021MSXM139). The present study was also financially supported by the Programme for Science and Technology Department of Zhejiang Province (Grant No. LGF18H220001), the Zhejiang Province Health Department (Grant No. 2018253605) and the Science and Technology Department of Lishui City (Project No. 2017ZDXK05)."