Safety and immunogenicity of inactivated SARS-CoV-2 vaccines in people living with HIV

作者全名："Ao, Ling; Lu, Ting; Cao, Yu; Chen, Zhiwei; Wang, Yuting; Li, Zisheng; Ren, Xingqian; Xu, Pan; Peng, Mingli; Chen, Min; Zhang, Gaoli; Xiang, Dejuan; Cai, Dachuan; Hu, Peng; Shi, Xiaofeng; Zhang, Dazhi; Ren, Hong"

作者地址："[Ao, Ling; Lu, Ting; Chen, Zhiwei; Wang, Yuting; Xu, Pan; Peng, Mingli; Chen, Min; Zhang, Gaoli; Xiang, Dejuan; Cai, Dachuan; Hu, Peng; Shi, Xiaofeng; Zhang, Dazhi; Ren, Hong] Chongqing Med Univ, Affiliated Hosp 2, Inst Viral Hepatitis, Key Lab Mol Biol Infect Dis,Minist Educ,Dept Infe, Chongqing, Peoples R China; [Cao, Yu; Li, Zisheng; Ren, Xingqian] Peoples Hosp Tongliang Dist, Chongqing, Peoples R China"

通信作者："Shi, XF; Zhang, DZ; Ren, H (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Inst Viral Hepatitis, Key Lab Mol Biol Infect Dis,Minist Educ,Dept Infe, Chongqing, Peoples R China."

来源：EMERGING MICROBES & INFECTIONS

ESI学科分类：MICROBIOLOGY

WOS号：WOS:000783331800001

JCR分区：Q1

影响因子：13.2

年份：2022

卷号：11

期号：1

开始页：1126

结束页：1134

文献类型：Article

关键词：SARS-CoV-2 vaccine; COVID-19; PLWH; safety; humoral immune response

摘要："It is important to know the safety and efficacy of vaccination in immunocompromised people living with HIV (PLWH), but currently, there is limited data on the inactivated SARS-CoV-2 vaccines' safety and immune responses in PLWH. In this prospective observational study, 139 PLWH and 120 healthy controls were enrolled and monitored for 21-105 days after a two-dose vaccination. The safety, anti-receptor binding domain IgG (anti-RBD-IgG) and anti-spike-19G responses, and RBD-specific memory B cell (MBC) responses were evaluated. The overall adverse events within seven days were reported in 12.9% (18/139) of PLWH and 13.3% (16/120) of healthy controls. No serious adverse events occurred in both groups. Overall, the seroprevalence of anti-RBD-IgG in PLWH was significantly decreased (87.1% vs. 99.2%; p<0.001). The geometric mean end-point titer (GMT) of anti-RBD-IgG in PLWH was also reduced, especially in patients with CD4 counts <200 cells/mu L, regardless of age, gender, or HIV viral load. GMTs of anti-RBD-IgG in both PLWH and healthy controls declined gradually over time. Similar results were also observed in the anti-spike-19G response. The frequency of RBD-specific MBCs in PLWH decreased (p<0.05), and then remained stable over time. Lastly, through multivariate analysis, we found the factors that predicted a less robust response to inactivated vaccines in PLWH were a low CD4 count and long time interval after vaccination. In conclusion, inactivated vaccines are well-tolerated in PLWH but with low immunogenicity. Therefore, SARS-CoV-2 vaccines and booster doses should be given priority in PLWH, especially in patients with low CD4 counts."

基金机构："National Science and Technology Major Project of China [2017ZX10202203-007, 2017ZX10202203-008, 2018ZX10302206-003]; National Natural Science Foundation of China [81772198]; Natural Science Foundation of Chongqing, China [cstc2020jcyj-msxmX0389]; pilot project of clinical cooperation between traditional Chinese and western medicine for significant and complicated diseases of National Administration of Traditional Chinese Medicine: hepatic fibrosis"

基金资助正文："This work is supported by the National Science and Technology Major Project of China (2017ZX10202203-007, 2017ZX10202203-008, 2018ZX10302206-003) and a pilot project of clinical cooperation between traditional Chinese and western medicine for significant and complicated diseases of National Administration of Traditional Chinese Medicine: hepatic fibrosis. We also acknowledge the support of the National Natural Science Foundation of China (81772198), the Natural Science Foundation of Chongqing, China (cstc2020jcyj-msxmX0389)."