Homogeneous and heterogeneous risk and prognostic factors for lung metastasis in colorectal cancer patients

作者全名："Wang, Hongmei; Shan, Xuefeng; Zhang, Min; Qian, Kun; Shen, Zhengze; Zhou, Weiying"

作者地址："[Wang, Hongmei; Zhou, Weiying] Chongqing Med Univ, Dept Pharmacol, Coll Pharm, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China; [Wang, Hongmei; Zhou, Weiying] Chongqing Med Univ, Chongqing Key Lab Drug Metab, Chongqing 400016, Peoples R China; [Wang, Hongmei; Zhou, Weiying] Chongqing Med Univ, Key Lab Biochem & Mol Pharmacol Chongqing, Chongqing 400016, Peoples R China; [Wang, Hongmei; Shan, Xuefeng] Chongqing Med Univ, Dept Pharm, Affiliated Hosp 1, Chongqing 400016, Peoples R China; [Zhang, Min] Chongqing Med Univ, Sch Publ Hlth & Management, Dept Epidemiol & Hlth Stat, Chongqing 400016, Peoples R China; [Qian, Kun] Chongqing Med Univ, Dept Gastrointestinal Surg, Affiliated Hosp 1, Chongqing 400016, Peoples R China; [Shen, Zhengze] Yongchuan Hosp Chongqing Med Univ, Dept Pharm, 439 Xuanhua Rd, Chongqing 402160, Peoples R China"

通信作者："Zhou, WY (通讯作者)，Chongqing Med Univ, Dept Pharmacol, Coll Pharm, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China.; Shen, ZZ (通讯作者)，Yongchuan Hosp Chongqing Med Univ, Dept Pharm, 439 Xuanhua Rd, Chongqing 402160, Peoples R China."

来源：BMC GASTROENTEROLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000783478400002

JCR分区：Q3

影响因子：2.4

年份：2022

卷号：22

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Colorectal cancer; Lung metastasis; Risk factors; Prognosis; SEER

摘要："Background The lung is one of the most frequent distant metastasis sites in colorectal cancer (CRC) patients; however, lung metastasis risk and prognostic factors have not been comprehensively elucidated. This study aimed to identify the homogeneous and heterogeneous lung metastasis risk and prognostic factors in CRC patients using the Surveillance, Epidemiology, and End Results (SEER) database. Methods CRC patients registered in the SEER database between 2010 and 2016 were included to analyse risk factors for developing lung metastasis by using univariable and multivariable logistic regression. Patients diagnosed between 2010 and 2015 were selected to investigate prognostic factors for lung metastasis by conducting Cox regression. Kaplan-Meier analysis was used to estimate overall survival outcomes. Results A total of 10,598 (5.2%) patients with synchronous lung metastasis were diagnosed among 203,138 patients with CRC. The median survival time of patients with lung metastasis was 10.0 months (95% CI 9.6-10.5 months). Older age, unmarried status, uninsured status, poor histological differentiation, more lymphatic metastasis, CEA positivity, liver metastasis, bone metastasis and brain metastasis were lung metastasis risk and prognostic factors. Black patients and those with left colon, rectum, and stage T4 disease were more likely to develop lung metastasis, while patients with right colon cancer and no surgical treatment of the primary tumour had poor survival outcomes. Conclusion The incidence of lung metastasis in CRC patients was 5.2%. CRC patients with lung metastasis exhibited homogeneous and heterogeneous risk and prognostic factors. These results are helpful for clinical evaluation and individual treatment decision making."

基金机构：Innovation Research Group in Colleges and Universities Program of Chongqing Municipal Education Commission [CXQT20012]; Postgraduate Tutor Team Development Program of Chongqing Municipal Education Commission [dstd201807]

基金资助正文：This project was supported by the Innovation Research Group in Colleges and Universities Program of Chongqing Municipal Education Commission (No. CXQT20012) and the Postgraduate Tutor Team Development Program of Chongqing Municipal Education Commission (No. dstd201807).