Accelerated biological aging in COVID-19 patients

作者全名："Cao, Xue; Li, Wenjuan; Wang, Ting; Ran, Dongzhi; Davalos, Veronica; Planas-Serra, Laura; Pujol, Aurora; Esteller, Manel; Wang, Xiaolin; Yu, Huichuan"

作者地址："[Cao, Xue] Guizhou Prov Peoples Hosp, Dept Oncol, Guiyang, Guizhou, Peoples R China; [Cao, Xue; Wang, Xiaolin; Yu, Huichuan] Sun Yat Sen Univ, Affiliated Hosp 6, Guangdong Inst Gastroenterol, Guangdong Prov Key Lab Colorectal & Pelv Floor Di, Guangzhou, Guangdong, Peoples R China; [Cao, Xue; Yu, Huichuan] Sun Yat Sen Univ, Affiliated Hosp 6, Dept Colorectal Surg, Guangzhou, Guangdong, Peoples R China; [Li, Wenjuan] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Pulm & Crit Care Med, Guangzhou, Guangdong, Peoples R China; [Wang, Ting] Thermo Fisher Sci Inc, Res & Dev, Los Angeles, CA USA; [Ran, Dongzhi] Univ Arizona, Coll Med, Dept Pharmacol, Tucson, AZ 85724 USA; [Ran, Dongzhi] Chongqing Med Univ, Dept Pharmacol, Key Lab Biochem & Mol Pharmacol, Chongqing, Peoples R China; [Davalos, Veronica; Esteller, Manel] Josep Carreras Leukaemia Res Inst IJC, Barcelona, Catalonia, Spain; [Planas-Serra, Laura; Pujol, Aurora] Bellvitge Biomed Res Inst IDIBELL, Neurometab Dis Lab, Barcelona, Catalonia, Spain; [Planas-Serra, Laura; Pujol, Aurora] ISCIII, Ctr Biomed Res Rare Dis CIBERER, Madrid, Spain; [Pujol, Aurora; Esteller, Manel] Inst Catalana Recerca & Estudis Avancats ICREA, Barcelona, Catalonia, Spain; [Esteller, Manel] Ctr Invest Biomed Red Canc CIBERONC, Madrid, Spain; [Esteller, Manel] Univ Barcelona UB, Sch Med & Hlth Sci, Physiol Sci Dept, Barcelona, Catalonia, Spain"

通信作者："Yu, HC (通讯作者)，Sun Yat Sen Univ, Affiliated Hosp 6, Guangdong Inst Gastroenterol, Guangdong Prov Key Lab Colorectal & Pelv Floor Di, Guangzhou, Guangdong, Peoples R China.; Yu, HC (通讯作者)，Sun Yat Sen Univ, Affiliated Hosp 6, Dept Colorectal Surg, Guangzhou, Guangdong, Peoples R China."

来源：NATURE COMMUNICATIONS

ESI学科分类：　

WOS号：WOS:000784997300022

JCR分区：Q1

影响因子：16.6

年份：2022

卷号：13

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："Chronological age is a risk factor for SARS-CoV-2 infection and severe COVID-19. Previous findings indicate that epigenetic age could be altered in viral infection. However, the epigenetic aging in COVID-19 has not been well studied. In this study, DNA methylation of the blood samples from 232 healthy individuals and 413 COVID-19 patients is profiled using EPIC methylation array. Epigenetic ages of each individual are determined by applying epigenetic clocks and telomere length estimator to the methylation profile of the individual. Epigenetic age acceleration is calculated and compared between groups. We observe strong correlations between the epigenetic clocks and individual's chronological age (r > 0.8, p < 0.0001). We also find the increasing acceleration of epigenetic aging and telomere attrition in the sequential blood samples from healthy individuals and infected patients developing non-severe and severe COVID-19. In addition, the longitudinal DNA methylation profiling analysis find that the accumulation of epigenetic aging from COVID-19 syndrome could be partly reversed at late clinic phases in some patients. In conclusion, accelerated epigenetic aging is associated with the risk of SARS-CoV-2 infection and developing severe COVID-19. In addition, the accumulation of epigenetic aging from COVID-19 may contribute to the post-COVID-19 syndrome among survivors. Age is a risk factor for SARS-CoV-2 infection and severe disease. Here the authors perform DNA methylation analyses in whole blood from COVID-19 patients using established epigenetic clocks and telomere length estimators, and describing correlations between epigenetic aging and the risk of SARS-CoV-2 infection and severe disease."

基金机构："National Natural Science Foundation of China [81902877]; Natural Science Foundation of Guangdong Province [2022A1515012656, 2018A0303130303]; ""La Marato de TV3"" Foundation [565/C/2021]; Program of Introducing Talents of Discipline to Universities; National Key Clinical Discipline"

基金资助正文："This study was funded by the National Natural Science Foundation of China (81902877, HY), the Natural Science Foundation of Guangdong Province (2022A1515012656, HY; 2018A0303130303, HY), the ""La Marato de TV3"" Foundation (565/C/2021) to AP and ME, the Program of Introducing Talents of Discipline to Universities, and the National Key Clinical Discipline (2012)."