Janus-like BxC/C Quantum Sheets with Z-Scheme Mechanism Strengthen Tumor Photothermal-Immunotherapy in NIR-II Biowindow

作者全名："Lu, Shi-Yu; Wang, Jingjing; Wang, Xingyue; Yang, Wenting; Jin, Meng; Xu, Luen; Yang, Huawei; Ge, Xiaoxiao; Shang, Changshuai; Chao, Yuguang; Zhou, Lei; Yin, Kun; Zhang, Qinghua; Gu, Lin; Cao, Yang; Ran, Haitao; Guo, Shaojun; Liu, Hui"

作者地址："[Lu, Shi-Yu; Wang, Jingjing; Yang, Wenting; Xu, Luen; Liu, Hui] Southwest Univ, Sch Mat & Energy, Minist Educ, Key Lab Luminescence Anal & Mol Sensing, Chongqing 400715, Peoples R China; [Lu, Shi-Yu; Wang, Jingjing; Yang, Huawei; Ge, Xiaoxiao; Shang, Changshuai; Chao, Yuguang; Zhou, Lei; Yin, Kun; Guo, Shaojun] Peking Univ, BIC ESAT, Beijing 100871, Peoples R China; [Lu, Shi-Yu; Wang, Jingjing; Yang, Huawei; Ge, Xiaoxiao; Shang, Changshuai; Chao, Yuguang; Zhou, Lei; Yin, Kun; Guo, Shaojun] Peking Univ, Sch Mat Sci & Engn, Beijing 100871, Peoples R China; [Lu, Shi-Yu; Jin, Meng] Chongqing Univ Sci & Technol, Coll Met & Mat Engn, Chongqing 401331, Peoples R China; [Wang, Xingyue; Cao, Yang; Ran, Haitao] Chongqing Med Univ, Inst Ultrasound Imaging, Chongqing Key Lab Ultrasound Mol Imaging, Affiliated Hosp 2, Chongqing 400010, Peoples R China; [Wang, Xingyue] Hubei Univ Arts & Sci, Affiliated Hosp, Xiangyang Cent Hosp, Xiangyang 441053, Hubei, Peoples R China; [Jin, Meng] Tsinghua Univ, Dept Chem, 30 Shuangqing Rd, Beijing 100084, Peoples R China; [Ge, Xiaoxiao] Capital Med Univ, Beijing Inst Brain Disorders, Beijing 100069, Peoples R China; [Zhang, Qinghua; Gu, Lin] Chinese Acad Sci, Inst Phys, Beijing Natl Lab Condensed Matter Phys, Beijing 100190, Peoples R China"

通信作者："Liu, H (通讯作者)，Southwest Univ, Sch Mat & Energy, Minist Educ, Key Lab Luminescence Anal & Mol Sensing, Chongqing 400715, Peoples R China.; Guo, SJ (通讯作者)，Peking Univ, BIC ESAT, Beijing 100871, Peoples R China.; Guo, SJ (通讯作者)，Peking Univ, Sch Mat Sci & Engn, Beijing 100871, Peoples R China.; Ran, HT (通讯作者)，Chongqing Med Univ, Inst Ultrasound Imaging, Chongqing Key Lab Ultrasound Mol Imaging, Affiliated Hosp 2, Chongqing 400010, Peoples R China."

来源：SMALL METHODS

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:000785894000001

JCR分区：Q1

影响因子：12.4

年份：2022

卷号：6

期号：6

开始页：　

结束页：　

文献类型：Article

关键词：BxC@C; metal-free; photothermal therapy; tumors; ultrathin quantum sheets

摘要："Carbon dots (CDs) are one of the most popular photothermal agents (PTAs) as a noninvasive strategy for tumor treatment. However, because of the inherent dominant fluorescent emission, the CDs-based PTAs hardly achieve a single photothermal conversion, which causes low photothermal conversion efficiency and poor photothermal performance. In this regard, finding a new CDs-based material system to greatly restrain its fluorescence to enhance its photothermal conversion efficiency is highly required, however, it is still a grand challenge. Herein, a kind of Z-scheme CDs-based PTAs consisting of 2D ultrathin nonmetallic BxC/C Janus quantum sheets (BxC/C JQSs) is reported to greatly enhance the photothermal conversion efficiency. It is demonstrated that the heterogeneous growth of Z-scheme BxC/C JQSs enables the NIR-driven quick injection of hot electrons from C into the conjugated BxC, realizing a single conversion of light to heat, and resulting in a high photothermal conversion of 60.0% in NIR-II. Furthermore, these new Z-scheme BxC/C-polyethylene glycol JQSs display outstanding biocompatibility and show effective tumor elimination outcome both in vitro and in vivo through the synergistic photothermal-immunotherapy in the NIR-II biowindow with undetectable harm to normal tissues."

基金机构："National Natural Science Foundation of China [51703184, 81630047]; Postdoctoral Science Foundation of China [2020M670021]; Young Elite Scientists Sponsorship Program by CAST [2021QNRC001]; Fundamental Research Funds for the Central Universities from Southwest University [XDJK2018B007]; Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and Devices, and Innovation Teams in Colleges and Universities of Chongqing [CXQT20005]"

基金资助正文："This work was financially supported by National Natural Science Foundation of China (51703184, 81630047), the Postdoctoral Science Foundation of China (2020M670021), Young Elite Scientists Sponsorship Program by CAST (2021QNRC001) and the Fundamental Research Funds for the Central Universities from Southwest University (XDJK2018B007). This research was also supported by Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and Devices, and Innovation Teams in Colleges and Universities of Chongqing (CXQT20005)."