High Neutrophil-lymphocyte Ratio Predicts Serious Renal Insufficiency in Patients with Lupus Nephritis

作者全名："Tang, Dijiao; Tang, Qi; Zhang, Long; Wang, Hongxu"

作者地址："[Tang, Dijiao; Wang, Hongxu] Chongqing Med Univ, Dept Lab Med, Affiliated Hosp 1, Chongqing, Peoples R China; [Tang, Qi] Shandong Univ, Shandong Prov Hosp, Dept Clin Lab, Cheeloo Coll Med, Jinan, Shandong, Peoples R China; [Zhang, Long] Peoples Hosp Jiulongpo Dist, Dept Urinary Surg, Chongqing, Peoples R China"

通信作者："Wang, HX (通讯作者)，Dept Lab Med, 1 Youyi Rd, Chongqing 400016, Peoples R China."

来源：IRANIAN JOURNAL OF IMMUNOLOGY

ESI学科分类：IMMUNOLOGY

WOS号：WOS:000788076600005

JCR分区：Q4

影响因子：0.9

年份：2022

卷号：19

期号：1

开始页：49

结束页：57

文献类型：Article

关键词：Lupus nephritis; Neutrophil-lymphocyte ratio; Renal insufficiency; Systemic lupus erythematosus

摘要："Background: Lupus nephritis (LN) is one of the most serious complications of systemic lupus erythematosus (SLE).The neutrophil to lymphocyte ratio (NLR) is a promising predictor and prognostic factor. An increased NLR is associated with a poor prognosis of several inflammatory diseases. Objective: To evaluate the value of NLR in the diagnosis and pre assessment of the disease severity of LN. Methods: This retrospective study included 88 patients with LN, 51 SLE patients without kidney involvement, 79 patients with primary chronic nephritis (CN), and 52 healthy controls (HC). The differences among these four groups and diagnostic value of NLR for patients with LN were evaluated. Results: The NLR of patients with LN before treatment was significantly higher than that of the other three groups. NLR positively correlated with C-reactive protein (CRP), complement 3(C3), C4, and serum creatinine (SCr) (CRP: r=0.337, p=0.007; C3: r=0.222, p=0.042; C4: r=0.230, p=0.035; SCr: r=0.408, p<0.0001) but negatively correlated with total serum IgG (r=-0.226, p=0.041). The level of NLR increased with the severity of renal dysfunction NLR (area under the curve: 0.785, 95% CI: 0.708-0.862) was useful for the diagnosis of LN, and its optimal cut-off value was 5.44 (sensitivity: 65.9%, specificity: 86.3%). Conclusions: NLR would be useful for the diagnosis of LN and reflects the severity of renal dysfunction Therefore, evaluating NLR before treatment could help clinicians to identify potential renal involvement in patients with SLE and distinguish LN from CN."

基金机构：　

基金资助正文：