A novel bioactive polyurethane with controlled degradation and L-Arg release used as strong adhesive tissue patch for hemostasis and promoting wound healing

作者全名："Zou, Faxing; Wang, Yansen; Zheng, Yudong; Xie, Yajie; Zhang, Hua; Chen, Jishan; Hussain, M. Irfan; Meng, Haoye; Peng, Jiang"

作者地址："[Zou, Faxing; Wang, Yansen; Zheng, Yudong; Xie, Yajie; Chen, Jishan; Hussain, M. Irfan] Univ Sci & Technol Beijing, Sch Mat Sci & Engn, Beijing 10083, Peoples R China; [Zhang, Hua] Chongqing Med Univ, Affiliated Hosp 1, Chongqing, Peoples R China; [Meng, Haoye; Peng, Jiang] Chinese Peoples Liberat Army Gen Hosp, PLA Inst Orthoped, Beijing Key Lab Regenerat Med Orthoped, Key Lab Musculoskeletal Trauma & War Injuries, Beijing, Peoples R China"

通信作者："Zheng, YD (通讯作者)，Univ Sci & Technol Beijing, Sch Mat Sci & Engn, Beijing 10083, Peoples R China.; Zhang, H (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Chongqing, Peoples R China.; Peng, J (通讯作者)，Chinese Peoples Liberat Army Gen Hosp, PLA Inst Orthoped, Beijing Key Lab Regenerat Med Orthoped, Key Lab Musculoskeletal Trauma & War Injuries, Beijing, Peoples R China."

来源：BIOACTIVE MATERIALS

ESI学科分类：　

WOS号：WOS:000788693000002

JCR分区：Q1

影响因子：18.9

年份：2022

卷号：17

期号：　

开始页：471

结束页：487

文献类型：Article

关键词：Tissue adhesive; Pro-angiogenic; Biodegradable safety; Arginine-based polyurethane; Hemostasis

摘要："Effective strategy of hemostasis and promoting angiogenesis are becoming increasingly urgent in modern medicine due to millions of deaths caused by tissue damage and inflammation. The tissue adhesive has been favored as an optimistic and efficient path to stop bleeding, while, current adhesive presents limitations on wound care or potential degradation safety in clinical practice. Therefore, it is of great clinical significance to construct multifunctional wound adhesive to address the issues. Based on pro-angiogenic property of L-Arginine (L-Arg), in this study, the novel tissue adhesive (G-DLPUs) constructed by L-Arg-based degradable polyurethane (DLPU) and GelMA were prepared for wound care. After systematic characterization, we found that the G-DLPUs were endowed with excellent capability in shape-adaptive adhesion. Moreover, the L-Arg released and the generation of NO during degradation were verified which would enhance wound healing. Following the in vivo biocompatibility was verified, the hemostatic effect of the damaged organ was tested using a rat liver hemorrhage model, from which reveals that the G-DLPUs can reduce liver bleeding by nearly 75% and no obvious inflammatory cells observed around the tissue. Moreover, the wound care effect was confirmed in a mouse full-thickness skin defect model, showing that the hydrogel adhesive significantly improves the thickness of newly formed dermis and enhance vascularization (CD31 staining). In summary, the G-DLPUs are promising candidate to act as multifunctional wound care adhesive for both damaged organ and trauma."

基金机构："National Natural Science Foundation of China [51973018, 51773018]; Fundamental Research Funds for the Central Universities [FRF-TP-17-001A2]; Beijing Municipal Science and Technology Commission Projects [Z191100002019017]"

基金资助正文："This work was financially supported by National Natural Science Foundation of China (Grant No.51973018, 51773018); Fundamental Research Funds for the Central Universities (FRF-TP-17-001A2); Beijing Municipal Science and Technology Commission Projects (No. Z191100002019017)."