Shear-responsive boundary-lubricated hydrogels attenuate osteoarthritis

作者全名："Lei, Yiting; Wang, Xingkuan; Liao, Junyi; Shen, Jieliang; Li, Yuling; Cai, Zhengwei; Hu, Ning; Luo, Xiaoji; Cui, Wenguo; Huang, Wei"

作者地址："[Lei, Yiting; Liao, Junyi; Shen, Jieliang; Hu, Ning; Luo, Xiaoji; Huang, Wei] Chongqing Med Univ, Orthoped Lab, Dept Orthoped, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China; [Wang, Xingkuan; Li, Yuling] North Sichuan Med Coll, Dept Orthopaed, Affiliated Hosp, 1 South Maoyuan Rd, Nanchong 637000, Sichuan, Peoples R China; [Cai, Zhengwei; Cui, Wenguo] Shanghai Jiao Tong Univ, Ruijin Hosp, Shanghai Key Lab Prevent & Treatment Bone & Joint, Dept Orthopaed,Sch Med,Shanghai Inst Traumatol &, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China"

通信作者："Luo, XJ; Huang, W (通讯作者)，Chongqing Med Univ, Orthoped Lab, Dept Orthoped, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China.; Cui, WG (通讯作者)，Shanghai Jiao Tong Univ, Ruijin Hosp, Shanghai Key Lab Prevent & Treatment Bone & Joint, Dept Orthopaed,Sch Med,Shanghai Inst Traumatol &, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China."

来源：BIOACTIVE MATERIALS

ESI学科分类：　

WOS号：WOS:000788757800001

JCR分区：Q1

影响因子：18.9

年份：2022

卷号：16

期号：　

开始页：472

结束页：484

文献类型：Article

关键词：Boundary lubrication; Injectable hydrogels; Shear-responsive; Liposomes; Osteoarthritis

摘要："Lipid-based boundary layers formed on liposome-containing hydrogels can facilitate lubrication. However, these boundary layers can be damaged by shear, resulting in decreased lubrication. Here, a shear-responsive boundary-lubricated drug-loaded hydrogel is created by incorporating celecoxib (CLX)-loaded liposomes within dynamic covalent bond-based hyaluronic acid (HA) hydrogels (CLX@Lipo@HA-gel). The dynamic cross-linked network enables the hydrogel to get restructured in response to shear, and the HA matrix allows the accumulation of internal liposome microreservoirs on the sliding surfaces, which results in the formation of boundary layers to provide stable lubrication. Moreover, hydration shells formed surrounding the hydrogel can retard the degradation process, thus helping in sustaining lubrication. Furthermore, in vitro and in vivo experiments found that CLX@Lipo@HA-gels can maintain anabolic-catabolic balance, alleviate cartilage wear, and attenuate osteoarthritis progression by delivering CLX and shear-responsive boundary lubrication. Overall, CLX@Lipo@HA-gels can serve as shear-responsive boundary lubricants and drug-delivery vehicles to alleviate friction-related diseases like osteoarthritis."

基金机构："National Key Research and Devel-opment Program of China [2020YFA0908200]; National Natural Science Foundation of China [81873998, 32101104, 81972069]; Shanghai Jiao Tong University ""Medical and Research"" Program [ZH2018ZDA04]"

基金资助正文："This work was supported by the National Key Research and Devel-opment Program of China (2020YFA0908200) , the National Natural Science Foundation of China (81873998, 32101104 and 81972069) , and Shanghai Jiao Tong University ""Medical and Research"" Program (ZH2018ZDA04) ."