Altered Neural Reactivity in Adolescents With Nonsuicidal Self-Injury During Exposure to Self-Injury Related Cues: Electrophysiological Evidence From a Two-Choice Oddball Paradigm

作者全名："Zhou, Dong-Dong; Zhao, Lin; Ma, Ling-Li; Hu, Jin-Hui; Chen, Ran; Jiang, Zheng-Hao; He, Xiao-Qing; Peng, Xin-Yu; Liu, Xin-Yi; Li, Xiao; Chen, Wan-Jun; Wang, Wo; Kuang, Li"

作者地址："[Zhou, Dong-Dong; Hu, Jin-Hui; Chen, Ran; Jiang, Zheng-Hao; He, Xiao-Qing; Liu, Xin-Yi; Wang, Wo; Kuang, Li] Chongqing Med Univ, Univ Town Hosp, Mental Hlth Ctr, Chongqing, Peoples R China; [Zhao, Lin; Ma, Ling-Li; Peng, Xin-Yu; Li, Xiao; Chen, Wan-Jun; Kuang, Li] Chongqing Med Univ, Affiliated Hosp 1, Dept Psychiat, Chongqing, Peoples R China"

通信作者："Zhou, DD; Kuang, L (通讯作者)，Chongqing Med Univ, Univ Town Hosp, Mental Hlth Ctr, Chongqing, Peoples R China.; Kuang, L (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Psychiat, Chongqing, Peoples R China."

来源：FRONTIERS IN PSYCHIATRY

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:000789324800001

JCR分区：Q2

影响因子：4.7

年份：2022

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：nonsuicidal self-injury; event-related potentials; N2; P3; response inhibition; adolescent

摘要："BackgroundNonsuicidal self-injury (NSSI) may be a type of addiction, that is characterized by cue reactivity. We aimed to explore the behavioral performance and neural reactivity during exposure to self-injury cues in adolescents with NSSI and major depressive disorder (MDD). MethodsEighteen MDD patients, 18 MDD patients with NSSI, and 19 healthy controls (HC) were recruited to perform a two-choice oddball paradigm. All subjects were 12-18 years old. Neutral cues and self-injury related cues separately served as deviant stimuli. Difference waves in N2 and P3 (N2d and P3d) were derived from deviant waves minus standard waves. Accuracy cost and reaction time (RT) cost were used as behavioral indexes, while the N2d and P3d were used as electrophysiological indexes; the N2d reflects early conflict detection, and the P3d reflects the process of response inhibition. ResultsNo significant main effects of group or cue or an effect of their interaction were observed on accuracy cost and P3d latency. For RT cost, N2d amplitude, and N2d latency, there was a significant main effect of cue. For P3d amplitude, there was a significant main effect of cue and a significant group x cue interaction. In the NSSI group, the P3d amplitude with self-injury cues was significantly larger than that with neutral cues. However, there was no such effect in the MDD and HC groups. ConclusionsAdolescents with NSSI showed altered neural reactivity during exposure to self-injury cue. Further studies with larger sample sizes are needed to confirm our results."

基金机构：Science and Technology Bureau of Chongqing [cstc2020jcyj-msxmX0222]; National Natural Science Foundation of China [81971286]

基金资助正文：Funding This work was supported by a grant from the Science and Technology Bureau of Chongqing (cstc2020jcyj-msxmX0222) and a grant from the National Natural Science Foundation of China (81971286).