"Risk of incident atrial fibrillation with low-to-moderate alcohol consumption is associated with gender, region, alcohol category: a systematic review and meta-analysis"

作者全名："Yang, Lingzhi; Chen, Huaqiao; Shu, Tingting; Pan, Mingyong; Huang, Wei"

作者地址："[Yang, Lingzhi; Chen, Huaqiao; Shu, Tingting; Huang, Wei] Chongqing Med Univ, Affiliated Hosp 1, Dept Cardiol, Chongqing 400016, Peoples R China; [Pan, Mingyong] Chongqing Univ, Coll Math & Stat, 174 Shazhengjie, Chongqing 400044, Peoples R China"

通信作者："Huang, W (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Cardiol, Chongqing 400016, Peoples R China."

来源：EUROPACE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000790044200001

JCR分区：Q1

影响因子：6.1

年份：2022

卷号：24

期号：5

开始页：729

结束页：746

文献类型：Review

关键词：Atrial fibrillation; Risk factors; Low-to-moderate alcohol consumption; Meta-analysis

摘要："Aims The association between low-to-moderate alcohol consumption and atrial fibrillation (AF) has yet to be fully elucidated. The main purpose of this meta-analysis was to estimate the risk of incident AF related to low-to-moderate alcohol consumption. Methods and results A meta-analysis was performed on 13 publications discussing the estimated risk for AF with habitual low-to-moderate alcohol intake in 10 266 315 participants. Graphical augmentations to the funnel plots were used to illustrate the potential impact of additional evidence on the current meta-analysis. Thirteen eligible studies were included in this meta-analysis. We found that moderate alcohol consumption was associated with an increased risk of incident AF in males [hazard ratio (HR) 1.09, 95% confidence interval (CI): 1.07-1.11, P < 0.00001], Europeans (HR 1.32, 95% CI: 1.23-1.42, P < 0.00001), and Asians (HR 1.09, 95% CI: 1.07-1.11, P < 0.00001). Moderate beer consumption was associated with an increased risk of developing AF (HR 1.11, 95% CI: 1.02-1.21, P = 0.01). Low alcohol consumption conferred an increased risk of AF in males (HR 1.14, 95% CI: 1.01-1.28, P = 0.04) and Europeans (HR 1.12, 95% CI: 1.07-1.17, P < 0.00001). Conclusions This analysis represents the increased risk of incident AF in males, Europeans, and Asians at moderate alcohol consumption levels and in males and Europeans at low alcohol consumption levels. Those who drink any preferred alcohol beverage at moderate levels should be cautious for incident AF. More studies are warranted to find those factors that influence alcohol's effect on predisposing AF."

基金机构："Chongqing Municipal Health and Health Committee [ZQNYXGDRCGZS2019001, 2019ZY3340, 2016HBRC001]"

基金资助正文："This work was supported by the Chongqing Municipal Health and Health Committee (ZQNYXGDRCGZS2019001, 2019ZY3340, 2016HBRC001)."