Effect of antidepressants on functioning and quality of life outcomes in children and adolescents with major depressive disorder: a systematic review and meta-analysis

作者全名："Teng, Teng; Zhang, Zhihan; Yin, Bangmin; Guo, Tingting; Wang, Xiaoya; Hu, Jiayi; Ran, Xin; Dai, Qi; Zhou, Xinyu"

作者地址："[Teng, Teng; Zhang, Zhihan; Yin, Bangmin; Guo, Tingting; Wang, Xiaoya; Hu, Jiayi; Ran, Xin; Dai, Qi; Zhou, Xinyu] Chongqing Med Univ, Dept Psychiat, Affiliated Hosp 1, Chongqing, Peoples R China; [Zhang, Zhihan; Guo, Tingting; Ran, Xin; Dai, Qi] Chongqing Med Univ, Clin Coll 1, Chongqing, Peoples R China; [Yin, Bangmin] Peoples Hosp Deyang City, Dept Neurol, Deyang, Peoples R China; [Wang, Xiaoya; Hu, Jiayi] Chongqing Med Univ, Clin Coll 2, Chongqing, Peoples R China"

通信作者："Zhou, XY (通讯作者)，Chongqing Med Univ, Dept Psychiat, Affiliated Hosp 1, Chongqing, Peoples R China."

来源：TRANSLATIONAL PSYCHIATRY

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:000790762400002

JCR分区：Q1

影响因子：6.8

年份：2022

卷号：12

期号：1

开始页：　

结束页：　

文献类型：Review

关键词：　

摘要："Functioning and quality of life (QOL) are typical outcomes assessed in children and adolescents with major depressive disorder (MDD); however, meta-analytical evidence remains scarce. The aim of this meta-analysis was to assess functioning and QOL antidepressant outcomes in this population. Eight electronic databases (PubMed, Cochrane Library, Web of Science, Embase, CINAHL, PsycINFO, LILACS, and ProQuest Dissertation Abstracts) were searched for double-blind randomized controlled trials (RCTs) up to July 31, 2020. RCTs that compared antidepressants with placebo for treating functioning and QOL in children and adolescents with MDD were included. Primary outcomes were mean change scores of functioning and QOL scales from baseline to post-treatment. Subgroup and sensitivity analyses were conducted to examine whether results were affected by moderator variables (e.g., medication type, age, sample size, and treatment duration). From 7284 publications, we included 17 RCTs (all 17 assessed functioning and 4 assessed QOL outcomes) including 2537 participants. Antidepressants showed significant positive effects on functioning (standardized mean difference [SMD] = 0.17, 95% confidence interval [CI] = 0.09-0.25, p < 0.0001) but not on QOL (SMD = 0.11, 95% CI = -0.02 to 0.24, p = 0.093), with no significant heterogeneity. The subgroup analysis showed that second-generation antidepressants (especially fluoxetine, escitalopram, and nefazodone), but not first-generation antidepressants, led to significant improvements in functioning. Antidepressants (especially second generation) improve functioning but not QOL in children and adolescents with MDD. However, well-designed clinical studies using large samples are needed to confirm these findings."

基金机构：National Natural Science Foundation of China [81873800]; Chongqing Science and Technology Commission [cstc2020jcyj-jqX0024]; Chongqing Postdoctoral Special Foundation [2010010006132663]

基金资助正文："This work was supported by the National Natural Science Foundation of China (Grant No. 81873800), institutional funds from the Chongqing Science and Technology Commission (Grant No. cstc2020jcyj-jqX0024), and Chongqing Postdoctoral Special Foundation (Grant No. 2010010006132663)."