Vitamin A Status Is More Commonly Associated With Symptoms and Neurodevelopment in Boys With Autism Spectrum Disorders-A Multicenter Study in China

作者全名："Yang, Ting; Chen, Li; Dai, Ying; Jia, Feiyong; Hao, Yan; Li, Ling; Zhang, Jie; Wu, Lijie; Ke, Xiaoyan; Yi, Mingji; Hong, Qi; Chen, Jinjin; Fang, Shuanfeng; Wang, Yichao; Wang, Qi; Jin, Chunhua; Chen, Jie; Li, Tingyu"

作者地址："[Yang, Ting; Chen, Li; Dai, Ying; Chen, Jie; Li, Tingyu] Childrens Hosp Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Chongqing Key Lab Childhood Nutr & Hlth, Minist Educ Key Lab Child Dev & Disorders, Chongqing, Peoples R China; [Jia, Feiyong] First Hosp Jilin Univ, Dept Dev & Behav Pediat, Changchun, Peoples R China; [Hao, Yan] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Pediat, Wuhan, Peoples R China; [Li, Ling] Hainan Women & Childrens Med Ctr, Dept Children Rehabil, Haikou, Peoples R China; [Zhang, Jie] Xian Childrens Hosp, Children Hlth Care Ctr, Xi'an, Peoples R China; [Wu, Lijie] Harbin Med Univ, Publ Hlth Coll, Dept Childrens & Adolescent Hlth, Harbin, Peoples R China; [Ke, Xiaoyan] Nanjing Brain Hosp, Child Mental Hlth Res Ctr, Nanjing, Peoples R China; [Yi, Mingji] Qingdao Univ, Affiliated Hosp, Dept Child Hlth Care, Qingdao, Peoples R China; [Hong, Qi] Maternal & Child Hlth Hosp Baoan, Shenzhen, Peoples R China; [Chen, Jinjin] Shanghai Jiao Tong Univ, Shanghai Childrens Hosp, Dept Child Healthcare, Shanghai, Peoples R China; [Fang, Shuanfeng] Zhengzhou Univ, Childrens Hosp, Zhengzhou, Peoples R China; [Wang, Yichao] Hunan Prov Maternal & Child Hlth Care Hosp, NHC Key Lab Birth Defect Res & Prevent, Changsha, Peoples R China; [Wang, Qi] Deyang Matern & Child Healthcare Hosp, Deyang, Sichuan, Peoples R China; [Jin, Chunhua] Capital Inst Pediat, Dept Children Hlth Care, Beijing, Peoples R China"

通信作者："Chen, J; Li, TY (通讯作者)，Childrens Hosp Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Chongqing Key Lab Childhood Nutr & Hlth, Minist Educ Key Lab Child Dev & Disorders, Chongqing, Peoples R China."

来源：FRONTIERS IN NUTRITION

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000791592500001

JCR分区：Q2

影响因子：5

年份：2022

卷号：9

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：autism spectrum disorder; vitamin A; neurodevelopment; clinical symptoms; sex differences

摘要："BackgroundAutism spectrum disorder (ASD) is a neurodevelopmental disorder, and show a striking male bias in prevalence. Vitamin A (VA) is essential for brain development, and abnormalities in its metabolite retinoic acid are associated with the pathophysiology of ASD. This national multicenter study was conducted to investigate the relationship between serum VA level and core symptoms in ASD children and whether there are still sex differences. MethodA total of 1,300 children with ASD and 1,252 typically-developing (TD) controls aged 2-7 years old from 13 cities in China were enrolled in this study. The symptoms of children with ASD were evaluated by the Autism Behavior Checklist (ABC), Social Responsiveness Scale (SRS), and Childhood autism rating scale (CARS). The neurodevelopmental level of the children was evaluated with the revised Children Neuropsychological and Behavior Scale (CNBS-R2016). The serum level of VA was measured by high-performance liquid chromatography (HPLC). ResultsThe serum VA level in children with ASD was significantly lower than that in TD children, especially in boys with ASD. Furthermore, VA levels in male children with ASD were lower than those in female children with ASD. In addition, we found that serum VA level was negatively correlated the SRS, CARS and communication warming behavior of CBNS-R2016 scores in boys with ASD. In terms of developmental quotients, serum VA level was positively associated with the general quotient, language quotient, gross motor quotient and personal-social quotient of boys with ASD, but no difference was found in girls with ASD. ConclusionsASD children, especially boys, have lower serum VA levels than TD children. Moreover, serum VA status is more commonly associated with clinical symptoms and neurodevelopment in boys with ASD."

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