Cigarette smoke-induced oxidative stress activates NRF2 to mediate fibronectin disorganization in vascular formation
作者全名:"Xue, Jinjiang; Liao, Qiong; Luo, Man; Hua, Chenfeng; Zhao, Junwei; Yu, Gangfeng; Chen, Xiangyu; Li, Xueru; Zhang, Xinchun; Ran, Ruiguo; Lu, Fanghui; Wang, Yingxiong; Qiao, Liangjun"
作者地址:"[Xue, Jinjiang; Wang, Yingxiong; Qiao, Liangjun] Chongqing Med Univ, Coll Basic Med, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China; [Xue, Jinjiang; Liao, Qiong; Luo, Man; Yu, Gangfeng; Chen, Xiangyu; Li, Xueru; Zhang, Xinchun; Ran, Ruiguo; Lu, Fanghui] Chongqing Med Univ, Inst Life Sci, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China; [Hua, Chenfeng; Zhao, Junwei] Zhengzhou Tobacco Res Inst CNTC, Key Lab Tobacco Chem, 2 Fengyang St, Zhengzhou 450001, Peoples R China"
通信作者:"Wang, YX; Qiao, LJ (通讯作者),Chongqing Med Univ, Coll Basic Med, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China."
来源:OPEN BIOLOGY
ESI学科分类:BIOLOGY & BIOCHEMISTRY
WOS号:WOS:000792699400003
JCR分区:Q2
影响因子:5.8
年份:2022
卷号:12
期号:4
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结束页:
文献类型:Article
关键词:cigarette smoke; oxidative stress; NRF2; STAT3; fibronectin; vascular formation
摘要:"Cigarette smoke significantly induces oxidative stress, resulting in cardiovascular disease. NRF2, a well-known antioxidative stress response factor, is generally considered to play protective roles in cardiovascular dysfunction triggered by oxidative stress. Interestingly, recent studies reported adverse effects of NRF2 on the cardiovascular system. These unfavourable pathogenic effects of NRF2 need to be further investigated. Our work shows that cigarette smoke extract (CSE)-induced oxidative stress disturbs fibronectin (FN) assembly during angiogenesis. Furthermore, this effect largely depends on hyperactive NRF2-STAT3 signalling, which consequently promotes abnormal FN deposition. Consistently, disruption of this pathway by inhibiting NRF2 or STAT3 prevents CSE-induced FN disorganization and vasculature disruption in human umbilical vein endothelial cells or zebrafish. Taken together, these findings demonstrate the cardiovascular dysfunction caused by CSE from a novel perspective that NRF2-dependent signalling engages in FN disorganization."
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